软脉灵口服液治疗血管性痴呆的临床疗效及其对SOD、VEGF及E_2、T等的影响  

Curative effect of Ruanmailing Oral Solution on vascular dementia and its influences on levels of SOD,VEGF,E_2 and T

作　　者：黄俊山[1] 张作丹 林坚[1] 李璟怡[3] 林求诚[4] 郑兴敏[1] 张维波[1] 

机构地区：[1]福建省福州市第一医院,福建350009 [2]泉州医学高等专科学校 [3]福建中医学院 [4]福建省中医药研究院

出　　处：《北京中医药大学学报》2009年第11期786-789,共4页Journal of Beijing University of Traditional Chinese Medicine

基　　金：福州市科技计划社会发展资助项目(No.2007-s-125)

摘　　要：目的探讨软脉灵口服液治疗血管性痴呆(VaD)患者的临床疗效及对血管性痴呆患者超氧化物歧化酶(SOD)、血管内皮生长因子(VEGF)、雌二醇(E_2)、睾酮(T)水平的影响。方法将60例VaD患者随机分为软脉灵口服液组(治疗组)及盐酸多奈哌齐治疗组(对照组)。采用单盲给药法,治疗组口服软脉灵口服液,每次1支(10 mL),每日3次,1个月为1疗程,连服3个疗程。对照组口服盐酸多奈哌齐(思博海),每次1片(5 mg),每日1次临睡前服用,疗程同治疗组。健康老年体检者(正常对照组)30例。检测SOD、VEGF、E_2、T。并观察各组患者治疗前后简易精神状态量表(MMSE)和日常生活量表(ADL)、中医症状积分等的变化。结果软脉灵口服液能显著提高VaD患者血浆SOD、VEGF水平(P<0.05),提高女VaD患者E_2值、男VaD患者T值及降低男VaD患者E_2值、E_2/T值(P<0.05或P<0.01),提高MMSE积分,降低ADL积分,改善临床症状。结论软脉灵口服液可有效防治血管性痴呆。Objective To investigate the curative effect of Ruanmailing Oral Solution on vascular dementia and its influences on the levels of superoxide dismutase（SOD）,vascular endothelial growth factor （VEGF）,estradiol（E2） and testosterone（T） in the patients with vascular dementia（VaD）.Methods All patents（n=60） were randomly divided into Ruanmailing Oral Solution group（treatment group） and Sibohai Tablets group（donepezil hydrochloside,control group）.The treatment group was given Ruanmailing Oral Solution thrice daily and one piece（10 mL） each time for 3 treatment courses（a course was for one month） by applying the single blind method.The control group was given Sibohai Tablets once daily and one table（5 mg） each time at sleeping time with the same course as the treatment group.The normal control group included 30 health old persons.The levels of SOD,VEGF,E2 and T were detected, and the integral changes of the Mini-Mental Status Examination（MMSE）,Activities of Daily Life（ADL） and TCM symptoms were observed.Results Ruanmailing Oral Solution increased significantly the levels of SOD and VEGF（P〈0.05）,E2 value in woman patients and T value in man patients,and decreased E2 value and E2/T value in man patients（P〈0.05 or P〈0.01）.The integral of MMSE was increased and ADL integral was decreased.The clinical symptoms were relieved.Conclusion Ruanmailing Oral Solution can be used to prevent and cure VaD effectively.

关 键 词：血管性痴呆 软脉灵口服液 临床观察 

分 类 号：R285.6[医药卫生—中药学]