戊乙奎醚、东莨菪碱和阿托品用于老年患者术前用药的比较  

Comparison of penehyclidine,scopolamine and atropine as premedications in the elderly

作　　者：疏树华[1] 潘建辉[1] 王瑞明[1] 方才[1] 

机构地区：[1]安徽医科大学附属省立医院麻醉科,合肥市230001

出　　处：《临床麻醉学杂志》2009年第12期1043-1045,共3页Journal of Clinical Anesthesiology

基　　金：安徽省卫生厅临床医学重点学科应用技术项目(编号:05A026)

摘　　要：目的比较术前抗胆碱药用于老年患者的临床效果。方法45例择期需要全麻且年龄≥65岁的老年手术患者,随机均分成A、B、C三组,麻醉前30min分别肌注戊乙奎醚0.01mg/kg、东茛菪碱0.3mg或阿托品0.5mg。记录用药前、用药后10、20、30min、气管插管后1min各时点SBP、DBP、HR、SpO2等指标,并用VAS评分评定患者口干程度。结果A组用药后SBP、DBP较用药前有下降趋势、HR减慢,气管插管后上述指标稍有上升;B、C组用药后30min及气管插管后1minSBP、DBP升高、HR增快明显(P<0.05),B组和C组用药后20min后SBP、DBP高于、HR快于A组(P<0.01)。注药后三组患者VAS口干评分均明显升高(P<0.01)。结论戊乙奎醚比东茛菪碱和阿托品更适合用于老年患者术前用药。Objective To compare the clinical effects of penehyclidine, scopolamine and atropine as premedieations in the elderly. Methods Forty-five patients aged ≥65 years old undergoing surgery and general anesthesia were randomly divided into three groups of A, B and C, who were given intramuscular injection of penehyclidine 0. 01 mg/kg, scopolamine 0.3 mg and atropine 0. 5 mg, respectively,at 30min before anesthesia. SBP,DBP, HR and SpO2 were recorded before injection,at 10,20,30 min after injection and at 1 min after intubation Degrees of thirst were evaluated by VAS scoring as well. Results SBP,DBP and HR were decreased slightly after injection in group A,which were increased in groups of B and C after injection at 30 min after injection and 1 min after intubation（P〈0. 05）. SBP,DBP and HR of groups of B and C were significantly higher than those of group A at 20 min after injection, Thirst score increased significantly after injection in three groups. Conclusion Penehyclidine as premedieation is more suitable for the elderly than scopolamine and atropine.

关 键 词：戊乙奎醚 东莨菪碱 阿托品 术前用药 老年 

分 类 号：R614[医药卫生—麻醉学]