针灸对SAMP8小鼠嗅球神经干细胞增殖分化的影响  

Influence of Acupuncture and Moxibustion on Proliferation and Differentiation of Neural Stem Cells in Olfactory Bulb of Senescence-accelerated Mouse P8

作　　者：唐勇[1] 乔秀兰[2] 尹海燕[1] 卢圣锋[1] 曾芳[1] 吴巧凤[1] 魏焦禄[1] 黄梅[1] 余曙光[1] 

机构地区：[1]成都中医药大学针灸推拿学院,成都610075 [2]重庆市中医院,重庆400013

出　　处：《生物医学工程学杂志》2009年第6期1295-1299,共5页Journal of Biomedical Engineering

基　　金：国家自然科学基金重大研究计划项目资助(90709032);四川省青年科技基金资助项目(09ZQ026-025);国家重点基础发展计划项目资助(2006CB504501;2009CB522903);四川省教育厅课题资助项目(200ZD004)

摘　　要：以SAMP8快速老化小鼠作为研究对象,采用BrdU/Nestin、BrdU/MAP-2和BrdU/β-tublinⅢ免疫荧光双标探讨针刺、艾灸治疗对嗅球神经干细胞增殖和向神经元分化的影响。研究结果表明,针刺、艾灸刺激均可促进SAMP8嗅球神经干细胞增殖;艾灸可能会促进SAMP8小鼠嗅球NSCs向神经元分化,但针刺刺激作用不明显。This study was carried out to defect the effects of acupuncture and moxibustion therapy on the proliferation and differentiation of neural stem cells in the olfactory bul of senescence-accelerated mouse PS. Immunofluorescence double staining methods（BrdU/Nestin,BrdU/MAP-2 and BrdU/β-tublin Ⅲ ） were used. The results show that both acupuncture and moxibustion could improve proliferation of neural stem cells, but only moxibustion could induce differentiation of neural stem cells into neuron.

关 键 词：针灸疗法 嗅球 神经干细胞 增殖 分化 

分 类 号：R245[医药卫生—针灸推拿学]