P物质对大鼠心脏自主神经功能的影响  

Effect of Substance P on Cardiac Autonomic Nervous Function in Rats

作　　者：邓丽君[1] 李静 严福平 陆杰[1] 

机构地区：[1]重庆医科大学基础医学院生理学教研室,重庆400016 [2]沙坪坝区凤凰镇初级中学校,重庆401334

出　　处：《生物医学工程学杂志》2009年第6期1320-1324,共5页Journal of Biomedical Engineering

摘　　要：采用心率变异性(HRV)分析方法,将40只SD大鼠分成5组:对照组、不同剂量SP组(5μg/kg、10μg/kg、20μg/kg)及spantide Ⅱ+SP组,观察各组静脉注射前后HRV各参数变化情况,探讨P物质对心脏自主神经功能的影响及其机制。结果显示(1)与正常对照组相比,SP不同剂量组各参数变化有显著性差异。MHP、APU、APH、TPV、RUH均升高,MHR、HCC则降低,峰值随剂量增加而增大,并提前出现。(2)spantideⅡ+SP组各HRV参数与大剂量SP组相比有显著差异。研究表明,静脉注入不同剂量SP后,心脏交感神经和副交感神经活性增强,心脏自主神经功能平衡失调和稳定性下降,这些效应均表现为剂量依赖性,并通过NK1受体介导产生。Forty SD rats were divided into 5 groups： control group, SP groups （5 μg/kg,10μg/kg,20 μg/kg） and spantide Ⅱ plus SP group. An analysis of heart rate variability （HRV） was used to detect the changes of HRV parameters before and after intravenous injection of SP in order to investigate the effect of substance P on cardiac autonomic nervous function and the corresponding mechanism. Results：（1）There were significant differences in most HRV parameters for the three different doses of SP. Mean heart period （MHP）, absolute power of ultra-low frequency and high frequency band （APU, APH）, total power（TPV） and ratio of power in ultra-low to high frequency band（RUH） increased, while mean heart rate（MHR） and chaos intensity （HCC） decreased during the 30 minutes. Each peak amplitude of HRV parameters went higher and showed up ahead of the upward doses of SP. （2）Significant change was seen in each of the parameters between spantide 11 plus SP group and high-dose SP group. These data idicate that, after intravenous injection of different doses of SP, both cardiac sympathetic nervous system activity and parasympathetic nervous system activity increase, and the function of cardiac autonomic nervous becomes instable and unbalanced. The effect of SP may be dose dependent, and it is possibly mediated by neurokinin-l（NK-1） receptor.

关 键 词：P物质 自主神经系统 心率变异性 NK-1受体 

分 类 号：R541[医药卫生—心血管疾病]