心血管植入材料体内内皮化研究进展  

Progress in Researches of In-Vivo Re-endothelialization at the Site of Implanting Cardiovascular Devices

作　　者：陈佳龙[1,2] 李全利[2] 陈俊英[2] 黄楠[2] 

机构地区：[1]西南交通大学生命科学与工程学院,成都610031 [2]西南交通大学材料先进技术教育部重点实验室,成都610031

出　　处：《生物医学工程学杂志》2009年第6期1380-1383,共4页Journal of Biomedical Engineering

基　　金：“973”项目资助(2005CB6239040);“863”项目资助(2006AA02A139);国家自然科学基金资助项目(30670564)

摘　　要：血管支架等心血管材料植入体内后的再狭窄及血栓形成问题仍然是亟待解决的重要难题。目前研究显示内皮细胞的损伤是再狭窄发生的重要原因。损伤部位快速内皮化将显著降低再狭窄比率,并避免血栓的形成,所以加快支架表面体内内皮化速度成为改善动脉粥样硬化介入治疗效果的重要方向。本文综述了国内外体内内皮化相关研究和血管支架的最新研究进展。Restenosis and thrombus at the site of implanting cardiovascular devices remains a significant problem in the practice of interventional cardiology. Recently, lots of studies reveal that endothelial impairment was considered as one of the most important mechanisms contributing to restenosis. The method of accelerating endothelial regeneration at the injury site could prevent restenosis and thrombus, so such methods are of importance for improving the effectiveness of interventional therapy for atherosclerosis. This paper summarized the progress in researches invivo re-endothelialization at the site of intravascular stent.

关 键 词：体内内皮化 再狭窄 血管支架 内皮祖细胞 

分 类 号：R318.08[医药卫生—生物医学工程]