寻常性银屑病患者白介素-18水平的变化及其意义  

Clinical Significance of Serum Interleukin-18 in Patients with Psoriasis Vulgaris

作　　者：罗权[1] 林玲[1] 李嘉彦[1] 朱慧兰[1] 何玉清[1] 周欣[1] 曾抗[2] 张锡宝[1] 

机构地区：[1]广州市皮肤病防治所,广州510095 [2]南方医科大学南方医院,广州510515

出　　处：《中国中西医结合皮肤性病学杂志》2009年第6期346-348,共3页Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine

基　　金：广东省自然科学基金(07001961);广州市医药卫生科研重点项目(2006-ZDi-07)

摘　　要：目的探讨白介素(IL)-18在寻常性银屑病发病中的作用及其血清水平检测的临床意义。方法应用双抗体夹心酶联免疫吸附法(ELISA)检测34例寻常性银屑病患者外周血清中IL-l8及干扰素(IFN)-γ的水平,并动态观察治疗前后IL-18及IFN-γ的变化及其与寻常性银屑病患者病情活动指标之间的关系。结果寻常性银屑病患者治疗前血清中IL-18及IFN-γ的水平较正常人对照组显著增高(P<0.01),且IL-18及IFN-γ的水平与寻常性银屑病的分期有关,其中进行期患者组显著高于静止期患者组(P<0.05)。治疗后血清中IL-18及IFN-γ较治疗前显著下降(P<0.05)。IL-18的血清浓度变化与寻常性银屑病严重程度指数PASI评分有相关性(P<0.05),且与IFN-γ水平呈显著正相关(P﹤0.05)。结论IL-18在寻常性银屑病的发病中可能起重要作用,血清IL-l8的检测可作为反映寻常性银屑病病情活动的指标之一。Objective To investigate the role and clinical significance of serum levels ofinterleukin（IL）-18 in patients with psoriasis vulgaris. Methods Serum levels of IL-18 and interferon （IFN）-γ were measured by double antibody sandwich enzyme-linked immnosorbent assay （ELISA） in 34 patients with psoriasis vulgaris. Results The serum levels of IL-18 and IFN-γ were significantly higher than those after treatment and in normal controls （P〈0.01）. And there was significant difference between the active stage and the resting stage of psoriasis vulgaris （P〈0.05）. The serum levels of IL-18 were associated with IFN-γ and PASI scores. Conclusion The IL-18 may be very important to the pathogenesis of psoriasis vulgaris.

关 键 词：银屑病 白介素-18 干扰素-Γ 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]