慢性荨麻疹患者血清白介素-4、白介素-6、白介素-8、白介素-10及IFN-γ的检测及临床意义  

Detection of the Serum Levels of Interleukin-4,Interleukin-6,Interleukin-8,Interleukin-10 and Interferon-γ in Patients with Chronic Urticaria

作　　者：毕鸣晔[1] 田玥[1] 黄海峰[1] 

机构地区：[1]江苏省无锡市人民医院,无锡214023

出　　处：《中国中西医结合皮肤性病学杂志》2009年第6期351-353,共3页Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine

摘　　要：目的探讨慢性荨麻疹患者血清细胞因子水平测定的临床意义。方法随机选择慢性荨麻疹患者32例,健康检查的正常人32名,分为两组,分别测定其血清中白介素(IL)-4、IL-6、IL-8、IL-10及干扰素(IFN)-γ的含量。结果慢性荨麻疹患者组血清中IL-4、IL-8水平显著高于正常对照组(均P<0.01);IL-6、IL-10水平略高于对照组,但差异无统计学意义(均P>0.05);而IFN-γ水平明显低于正常对照组(P<0.01)。结论慢性荨麻疹患者血清IL-4、IL-6、IL-8、IL-10及IFN-γ水平异常,提示慢性荨麻疹的发病与免疫机制有关。Objective To explore the clinical significance of chronic urticaria by detecting the levels of interleukin （IL）-4, IL-6, IL-8, IL-10 and interferon （IFN）-γ in the serum of patients with chronic urticaria. Methods 32 patients with chronic urticaria and 32 healthy people were divided into two groups. The serum levels of IL-4, IL-6, IL-8, IL-10 and IFN-γ were determined separately. Results The levels of IL-4 and IL-8 were significantly higher than those in healthy controls （P〈0.001）. The levels of IL-6 and IL-10 were slightly higher than those in healthy controls, but there were no difference （P〉0.05） ;while the level of IFN-γ was significantly lower than that in healthy controls （P〈0.001）. Conclusion Chronic urticaria may be related with immune defenee mechanism by means of the abnormal level of IL-4, IL-6, IL-8, IL-10 and IFN-γ of patients with chronic urticaria.

关 键 词：慢性荨麻疹 白介素 干扰素-Γ 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]