角膜上皮树突状细胞免疫学特性研究的现状  

Recent studies on the distribution and immune characterization of dendritic cells in the corneal epithelium

作　　者：陈文生[1] 刘祖国[1] 

机构地区：[1]厦门大学眼科研究所厦门大学附属厦门眼科中心,361005

出　　处：《中华眼科杂志》2009年第12期1145-1148,共4页Chinese Journal of Ophthalmology

摘　　要：角膜上皮内存在的朗格罕细胞型树突状细胞具有吞噬、加工、递呈抗原及激发T细胞的能力。这些细胞是“职业的”抗原递呈细胞，在眼表免疫系统中起关键的免疫监视作用。近期，有研究证明在正常的角膜缘上皮基底层存在具有慢周期特性的、表达角膜缘干细胞标识物-ATP粘连转运蛋白家族G2成员（ABCG2）的树突状细胞。进一步研究发现，中央角膜炎症反应早期可以诱导角膜缘上皮基底层表达主要组织相容性复合体Ⅱ型抗原的树突状细胞密度增加并向角膜中央迁移。这些研究提示角膜缘上皮基底层内存在的树突状细胞是角膜炎症反应发生过程中的重要参与者。Langerhans cell-type dendritic cells （DCs） present in the corneal epithelium are capable of taking up, processing, and presenting antigens, leading to the initiation of T-lymphocyte responses. These cells are the professional antigen-presenting cells （APCs） of the corneal epithelium and serves as the critical sentinel cells of the immune system in the ocular surface. A recent study has demonstrated that normal limbal basal epithelium is in fact endowed with a small number of slow-cycling DCs with expression of a limbal stem cell marker, ABCG2. Furthermore, it has been found that central corneal inflammation induces recruitment of major histocompatibility complex （MHC） class II ^＋ DCs from limbal basal epithelium. These findings suggest that limbal basal epithelial DCs play an impoatant role in corneal inflammatory reaction.

关 键 词：上皮 角膜 树状细胞 抗原呈递 T淋巴细胞 

分 类 号：R686[医药卫生—骨科学]