曲匹地尔及阿斯匹林对球囊血管成形术后血管增生及重构的影响  

Effect of trapidil and aspirin on proliferation and artery remodeling after balloon angioplasty

作　　者：戴秋艳[1,2] 郑道声[1,2] 何奔[1,2] 刘建平 盖保康[1,2] 

机构地区：[1]上海第二医科大学附属仁济医院心内科 [2]山东省立医院心内科

出　　处：《中国药理学通报》1998年第4期356-358,共3页Chinese Pharmacological Bulletin

摘　　要：目的从血管病理角度观察血小板源生长因子（ＰＤＧＦ）抑制剂曲匹地尔（ｔｒａｐｉｄｉｌ）及血小板抑制剂阿斯匹林（ａｓｐｉｒｉｎ）对血管球囊成形术后内膜增生及重构的影响，为临床用药提供实验依据。方法对实验兔行髂动脉球囊成形术，术前３ｄ分别用ｔｒａｐｉｄｉｌ（２５ｍｇ·ｄ－１）及ａｓｐｉｒｉｎ（２５ｍｇ·ｄ－１），至术后２８ｄ取病变血管段切片染色，用计算机图像分析血管内膜、中膜厚度和腔面积、平均动脉面积的变化。结果ｔｒａｐｉｄｉｌ使腔面积扩大，平均动脉面积（外弹力膜内横截面积ＥＥＬ）增加明显，而ａｓｐｉｒｉｎ腔面积较ｔｒａｐｉｄｉｌ减少但较对照扩大，ＥＥＬ较对照及ｔｒａｐｉｄｉｌ组比较均减少。结论ｔｒａ－ｐｉｄｉｌ和ａｓｐｉｒｉｎ均抑制血管增生反应（以中膜平滑肌细胞为主）。AIM To know the effection of trapidil (PDGF antagonist) and aspirin (an antiplatelet drug) on proliferation and remodeling of rabbits iliac artery after balloon angioplasty. METHODS Giving the iliac artery balloon angioplasty to rabbits and using the trapidil and aspirin 25 mg·day -1 (raspectively) before the operation last to 28 day after operation, and then local vessel was required for pathological analysis from computer image. RESULT The luminal area and EEL area were significantly larger in trapidil treated group than aspirin and control groups, Luminal area larger in aspirn treated group than controls but less than trapidil group. EEL area was less in aspirin than trapidil and control. CONCLUSION Trapidil and aspirin both inhibit proliferation of vessel after balloon injury but only trapidil obviously interferes with artery remodeling process.

关 键 词：曲匹地尔 阿斯匹林 血管重构 血管成形术 

分 类 号：R654.3[医药卫生—外科学] R973.2[医药卫生—临床医学]