螺旋藻多糖的抗衰老作用  

Anti aging effects of polysaccharide of spirulina platenisis

作　　者：刘玉兰[1,2] 牟孝硕[1,2] 颜鸣 崔素玉[1,2] 许红霞 罗晓[1,2] 

机构地区：[1]沈阳药科大学药理学教研室 [2]沈阳军区总医院药理室

出　　处：《中国药理学通报》1998年第4期362-364,共3页Chinese Pharmacological Bulletin

摘　　要：目的研究螺旋藻多糖的抗衰老作用。方法ＭＤＡ和ＳＯＤ测定分别采用ＴＢＡ法和亚硝酸盐法，脂褐质的测定采用荧光分光光度法。结果螺旋藻多糖能延长果蝇的平均寿命，提高低温（－５℃）环境下的存活率并能降低果蝇脂褐质含量。小鼠灌服２５０ｍｇ·ｋｇ－１螺旋藻多糖能降低老龄小白鼠肝、脑脂质过氧化物，提高老龄小白鼠血浆中ＳＯＤ活性。AIM To investigate the anti aging effects of polysacharide of spirulina platenisis.METHODS MDA,SOD and lipofuscin were determined with TBA,nitrite and fluorometry respecitively. RESULTS The mean life was prolonged, lipofuscin levels were decreased, and the rate of live in hypotemperature with -5℃ was increased in drosphila metanogaster by administration of polysaccharide of spirulina platenisis. The LPO in liver and brain was decreased, and the level of SOD in serum was increased in 18 month mice. CONCLUSION The anti aging effects of polysaccharide of spirulina platenisis were shown. The decrease of LPO and increase of SOD was its mechanism of anti aging.

关 键 词：螺旋藻多糖 过氧化脂质 超氧化歧化酶 抗衰老药 

分 类 号：R977.9[医药卫生—药品]