长江以北唇腭裂患者中先天性心脏病的发生率及其特点  

Prevalence of congenital heart diseases in oral cleft patients in north of Changjiang river

作　　者：潘国忠[1] 尚云霄[1] 李武德[2] 邹阳春[1] 吴迪[1] 刘鹏[1] 

机构地区：[1]北京煤炭总医院心血管内科,北京市100028 [2]北京煤炭总医院唇腭裂中心,北京市100028

出　　处：《中国心血管病研究》2009年第12期899-901,共3页Chinese Journal of Cardiovascular Research

摘　　要：目的探讨我国长江以北地区唇腭裂患者中先天性心脏病（简称先心病）的发生率及其特点。方法回顾性分析2005年1月至2009年5月收治的726例拟行唇腭裂修复术的患者。将患者分成单纯唇裂组（1组）、单纯腭裂组（2组）及唇裂合并腭裂组（3组），对三组患者均行彩色多普勒超声心动图检查，并对检查结果进行统计学分析。结果726例唇腭裂患者中共检出先天性心脏病43例（45个病变），其中房间隔缺损29个、室间隔缺损4个、动脉导管微闭8个、法洛四联症1个、主动脉狭窄2个、肺动脉狭窄1个，总发生率为5．92％；单纯唇裂组和单纯腭裂组患者先心病发生率分别为5．75％和7．60％，唇裂合并腭裂组患者先心病发生率为5．64％，三组患者的先心病发生率差异无统计学意义。结论唇腭裂患者先心病发生率较高，不同类型唇腭裂患者之间的发生率无明显差别。彩色多普勒超声心动图检查是唇腭裂患者的常规检查。Objective To explore the prevalence of congenital heart diseases（CHDs） in oral cleft patients in north of Changjiang river. Methods 726 cases with cleft lip and/or palate from January 2005 to May 2009 were retrospective studied, a Doppler echocardiogram with colorful mapping was obtained in all patients. The patients were classified into three categories; group 1- cleft lip alone; group 2： cleft plate alone and group 3： cleft lip and palate. Results 43 patients（45 lesions） were diagnosed to have CHDs in 726 patients （5.92%）： 29 atrial septal defects, 4 ventricular septal defects, 8 patent ductus arteriosus, 2 aortic stenosis, 1 ease of tetralogy of Fallot, 1 pulmonary stenosis. 13 cases of them were found in group 1 （5.75%）, 7 cases in group 2 （7.60%）, and 23 patients in group 3 （5.64%）. There was no significant difference in prevalence of CHDs among the three groups. Conclusion The prevalence of CHDs in oral cleft patients is high. The presence of CHD does not correlate with the type of clef. All oral clefts patients should receive routine examination by using of Doppler echocardiography.

关 键 词：先天性心脏病 唇腭裂 发生率 多普勒超声心动图 

分 类 号：R541.1[医药卫生—心血管疾病]