复圣散对高脂大鼠脑缺血复灌后红细胞变形性和血浆内皮素的影响  

Effects of Fusheng Powder on Erythrocytic Deformability and Plasmatic Endothelin in the Case of Cerebral Ischemia Undergone Re perfusion in the Rat with Hyperlipemia

作　　者：雷燕[1] 王蕴红[1] 鲁万强[2] 黄启福[1] 王永炎[1] 

机构地区：[1]北京中医药大学脑病研究室,北京100029 [2]河南中医学院附属一院,河南450000

出　　处：《北京中医药大学学报》1998年第5期20-22,共3页Journal of Beijing University of Traditional Chinese Medicine

基　　金：博士后基金资助课题!(No .0 5 4 3 2 )

摘　　要：通过喂饲高脂饮食造成高脂血症大鼠动物模型 ,在此基础上利用线栓法复制双侧颈总动脉脑缺血再灌注模型 ,以激光衍射法测定红细胞变形性 ,以放射免疫法测定血浆内皮素 (ET)。结果 :高脂大鼠脑缺血再灌后 1d ,红细胞变形性明显降低 ,聚集性升高 ,血浆ET也呈升高趋势 ,与正常对照组有显著差异 (P <0 0 5) ;再灌后 7d ,除血浆ET含量外 ,各项指标恢复正常 ;而中药复圣散具有明显降低高脂大鼠脑缺血再灌后红细胞聚集性、改善红细胞变形能力和抑制血浆ET分泌的作用 ,相关分析表明红细胞变形性与血浆ET显著相关。提示中药复圣散可通过降低红细胞聚集性 ,提高其变形能力 ,同时减少血浆ET的过量释放 ,而改善脑微循环灌注 ,保护脑缺血性损伤。The model of cerebral ischemia was induced in the rat with hyperlipemia; laser diffraction method was used to determine erythrocytic deformability and radioimmunoassay was used to determine the content of plasmatic entothelin. The results showed that 1 day after re perfusion of the cerebral ischemic rat, the erythrocytic deformability was obviously decreased, the erythrocytic aggregation ability was increased, and the content of plasmatic endothelin had an increasing tendency ( P <0.05); 7 days after the re perfusion, all the criteria but the content of plasmatic endothelin, were restored to normal level; and the TCM preparation Fusheng Powder had significant effects of decreasing erythrocytic aggregation ability, improving erythrocytic deformation ability, and inhibiting plasmatic endothelin secretion, by which Fusheng Powder improved cerebral microcirculation perfusion and protected the brain from cerebral ischemic damage.

关 键 词：脑缺血 再灌注损伤 复圣散 红细胞变形性 内皮素 

分 类 号：R277.733[医药卫生—中医学] R285.5