体复康对运动性疲劳大鼠脑组织L-ENK、DYNA_(1-13)动态变化的影响  

Effects of the TCM Preparation Tifukang on Dynamic Changes of L ENK and DYN A 1-13 in the Cerebral Tissue of the Rat with Exercise induced Fatigue

作　　者：陈家旭[1] 杨维益[1] 梁嵘[1] 董浩[1] 李峰[1] 王天芳[1] 刘晓兰[1] 康纯洁[1] 朱迎春[1] 

机构地区：[1]北京中医药大学,北京100029

出　　处：《北京中医药大学学报》1998年第5期23-25,共3页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家自然科学基金委重点资助!(NO .3 94 3 0 14 0 )

摘　　要：采用ABC免疫组织化学法结合图象分析 ,观察中药复方“体复康”对运动性疲劳大鼠不同脑区L ENK、DYNA1 - 1 3的动态变化。结果 :高强度长期 (共 7周 )运动的大鼠 ,安静状态下尾壳核L ENK下降 ;而在此基础上末次急性运动的大鼠 ,L ENK被迅速激活而升高。中药复方“体复康”具有调节L ENK的作用 ,表现在对急性运动中的下调 ,在对慢性运动应激中的上调。运动能激活下丘脑DYNA1 - 1 3,以运动结束后 3 0min最为明显 ;该方药在此强度下对疲劳大鼠恢复过程中的下丘脑DYNA1 - 1 3有一定的下调作用 ,但作用不甚明显。The methods of ABC immunohistochemistry and image pattern analysis were used to observe the effects of the TCM preparation Tifukang on dynamic changes of L ENK and DYN A 1-13 in different cerebral areas in the rat with exercise induced fatigue. The results showed that the content of L ENK in caudate putamen decreased when at rest in the rat undergone 7 week's exercise with high intensity, but increased immediately at the end of the exercise; and Tifukang had a regulating effect on the content of L ENK, making it decreased when in an acute stress state and increased when in a chronic stress state caused by exercise in rats. The results also showed that the content of DYN A 1-13 in hypothalama could be activated by exercise, and the activation was more obvious 30 minutes after the stopping of the exercise; and Tifukang could decrease the content of DYN A 1-13 in hypothalama but with no significant effect.

关 键 词：体复康 运动性疲劳 脑组织 L-ENK DYN A1-13 

分 类 号：R285.5[医药卫生—中药学]