肾上腺髓质素与肾上腺紧张素在维持性血透中的变化  

The Changes of ADM_(15-52) and ADM_(153-18)5 in Maintenance Hemodialysis

作　　者：张昭馥[1] 石湘芸[2] 赵云涛[2] 董葆[1] 张志勇[1] 田青 张肇康 唐朝枢[4] 

机构地区：[1]中国人民解放军海军总医院肾内科,北京100037 [2]中国人民解放军海军总医院心内科,北京100037 [3]美国凤凰公司 [4]北京医科大学心血管基础研究所

出　　处：《天津医药》1998年第9期515-518,共4页Tianjin Medical Journal

摘　　要：应用放免法测定32例维持性血透患者透析前后血浆肾上腺髓质素(ABM_(13-52))及前体肾上腺紧张素(ABM_(153-185))水平。发现ADM_13-52较正常人明显升高(P<0.01),而ADM_(153-185),则明显下降(P<0.01)。前者与MAP、血浆BUN、ET有明显相关性,r值分别为0.492、0.743、0.492,而后者与MAP、BUN、ET无相关。血液透析后ADM_(13-52)与ADM_(153-185)均无明显变化,它们的改变与BUN、Cr、HCO_3^-、K^+、Na^+、CL^-、MAP、渗透压等变化无关。提示ADM_(13-52)、ADM_(153-185)这种新发现的血管活性物质参与了循环与血压的调节,其平衡失调可能是肾性高血压的原因之一。血液透析的急性效果对ADM_(13-52)、ADM_(153-185)无明显影响。The levels of ADM13-52 and ADM153-185 in 32 patients were assayed by RIA. The results showed that ADM13-52 levels were markedly higher than those of the normal subjects(P<0.01) ,but ADM153-185 levels were markedly lower(P< 0.01). There was a positive relationship between ADM153-185 and mean arterial pressure (MAP), plasma BUN and ET, but ADM153-1855 was not. After dialysis both ADM13.52 and ADM153-185 did not change markedly. Their changes had no relation with the changes of BUN,Cr,HCO3- , K+ ,Na+ , Cl- , MAP and Osm. The results showed that ADM13-52 and ADM,53.185, which were newly found vaso-active substance,adjusted circuit and BP, their misadjustment may be one of the reasons which led to renal hypertension. The acute effect of HD does not affect ADM13-52 and ADM151-185 definitely.

关 键 词：肾上腺髓质素 ADM 肾性高血压 血液透析 

分 类 号：R544.140.5[医药卫生—心血管疾病] R459.5[医药卫生—内科学]