河南省驻马店市“艾滋病病毒单阳”家庭阴性配偶4种性病相关病毒感染调查  

Survey of HIV,HBV,HCV infections and syphilis among discordant HIV-infection couples in Zhumadian,Henan province

作　　者：葛增[1,2] 单多[1,2] 王璐[1] 高省[1] 丁国伟[1] 宋鲁平[3] 周建平[3] 何文生[3] 郭巍[1] 彭志行[4] 

机构地区：[1]北京协和医学院公共卫生学院,北京100050 [2]中国疾病预防控制中心性病艾滋病预防控制中心 [3]驻马店市疾病预防控制中心 [4]南京医科大学公共卫生学院

出　　处：《疾病监测》2009年第11期846-848,共3页Disease Surveillance

摘　　要：目的了解河南省驻马店市"艾滋病病毒(HIV)单阳"家庭阴性配偶HIV、病毒性乙型肝炎(乙肝)病毒(HBV)、病毒性丙型肝炎病毒(HCV)及梅毒感染现状及合并感染现状。方法采用普查方法,对河南省驻马店市"HIV单阳"家庭阴性配偶进行血清流行病学调查,采集阴性配偶的血标本,检测其HIV、HBV、HCV及梅毒感染状况。结果本次调查共采集"HIV单阳"家庭中HIV抗体阴性配偶血样3619份,经检测HIV抗体阳性49例,HIV感染率为1.35%,抗-HCV感染率为31.20%,且随着年龄的增加而逐步升高(趋势χ2=-3.78,P<0.01)、梅毒感染率为0.17%,但女性感染率高于男性(χ2=0.0061,P<0.01)、乙肝表面抗原(HBsAg)感染率为5.40%、乙肝"大三阳"[HBsAg、乙肝病毒e抗原(HBeAg)、乙肝病毒核心抗体(抗-HBc)]阳性率为0.77%,乙肝"小三阳"(HBsAg、抗-HBe、抗-HBc)阳性率为2.93%。HBsAg/HCV合并感染率最高为1.22%。HIV阳性者中,合并感染人数占的63.27%。结论驻马店市"HIV单阳"家庭阴性配偶的HIV感染率较高,已成为HIV感染的高危人群之一,4种传染病存在混合感染现象,建议加强对该人群的随访,定期检测HIV、HBV、HCV及梅毒,以控制4种传染病家庭内经性传播。Objective To understand the current status of HIV, hepatitis B virus （ HBV）, hepatitis C virus （HVC） infections and syphilis as well as the co-infections among the discordant HIV infection couples in Zhumadian, Henan province. Methods Seroepidemiological survey was conducted among the discordant HIV infection couples by taking blood samples from HIV negative husband or wife for HIV, HBV, HCV and syphilis detections. Results A total of 3 619 blood samples were taken, and 49 were HIV positive （ 1.35% ）, the infection rate of HCV was 31.20 %, which in creased with the age （χ^2 = - 3.78, P 〈 0.01 ）, syphilis infection rate was 0.17%, which was higher in women than in men, and HBsAg positive rate was 5.40%, The positive rate of HBsAg, HBeAg and HBcAb was 0.77% and the positive rate of HBsAg, HBeAb and HBcAb was 2.93%. HBsAg/HCV co-infection rate was highest （ 1.22 % ）, Coinfections occurred in 63.27 % of the HIV positive people. Conclusion HIV infection rate among the negative husband or wife was high among the discordant HIV infection couples in Zhumadian, which indicated that they had become the high risk population of HIV infection, Co-infections of HIV, HBV, HCV and syphilis were observed. It is suggested that the follow-up of the discordant HIV infection couples should be strengthened and regular HIV, HBV, HCV and syphilis detections should be conducted for them to control the disease transmission among this population.

关 键 词：艾滋病 HBV HCV 梅毒 

分 类 号：R512.91[医药卫生—内科学]