流行性乙型脑炎疫苗基础免疫血清学效果的Meta分析  

Meta-analysis on Serological Effect of the Primary Vaccination for Japanese Encephalitis of the Literatures

作　　者：尹遵栋[1] 罗会明[1] 李艺星[1] 李军宏[1] 宁桂军[1] 随海田[2] 梁晓峰[1] 

机构地区：[1]中国疾病预防控制中心免疫规划中心,北京100050 [2]北京市昌平区疾病预防控制中心,北京102200

出　　处：《中国疫苗和免疫》2009年第6期501-506,共6页Chinese Journal of Vaccines and Immunization

摘　　要：目的汇总、比较不同流行性乙型脑炎(乙脑)疫苗(Japanese Encephalitis Vaccine,JEV)基础免疫后抗体阳转率,评价血清学效果。方法电子检索《中国医院知识库》、《万方全文数据库》和西文生物医学期刊文献数据库,将研究JEV基础免疫后血清学效果的随机对照试验和非随机对照试验的文献全部纳入分析,用RevMan4.2.10软件进行统计分析。结果共纳入12篇文献,7篇有对照组。乙脑减毒活疫苗(JEV,Attenuated Live;JEV-L)、乙脑灭活疫苗(非洲绿猴肾细胞)[JEV,Inactivated(Vero Cell),JEV-I(Vero)]和乙脑灭活疫苗(原代地鼠肾细胞)[JEV-I(Primary Hamster Kidney Cell),JEV-I(PHK)]基础免疫后,抗体阳转率分别为86%[95%可信区间(ConfidenceInterval,CI):80%～91%]、83%(95%CI:72%～94%)和64%(95%CI:58%～69%)。3种疫苗基础免疫抗体阳转率两两比较,JEV-I(Vero)基础免疫后的抗体阳转率显著高于JEV-I(PHK),其他两两比较抗体阳转率的差异无统计学意义。结论JEV-L和JEV-I(Vero)基础免疫后血清学效果要高于JEV-I(PHK)。Objectives To summary and compare the different seroconversion rates after the primary vaccination for the Japanese encephalitis （JE）, and to evaluate the serological effect of 3 kinds of JE vaccines. Method Searching ＂CHKD＂, ＂Wanfang＂ database and ＂EMCC＂ databases, the studies of the immunogenicity after the primary JEV vaccination, all randomized controlled trials or non-randomized controlled trials were included, and statistical analysis were made by RevMan 4.2.10 software. Results A total of 12 literatures were included, 7 studies had control groups. The seroconversion rates after the primary vaccination, JEV-L, JEV-I （Vero） and JEV-I（PHK）, were 86% （95% CI： 80% - 91%）, 83% （95% CI： 72% 94%） and 64% （95% CI： 58% - 69%） respectively. Comparing the seroconversion rates of the 3 kinds of vaccines after primary immunization, the rate of JEV-I （Vero） was significantly higher than the rate of JEV- I（PHK）, other comparisons were no significant difference. Conclusion The serological effects of JEV-L and JEV-I （Vero） after the primary vaccination were higher than that of JEV-I （PHK）.

关 键 词：流行性乙型脑炎减毒活疫苗 流行性乙型脑炎灭活疫苗(非洲绿猴肾细胞) 流行性乙型脑炎灭活疫苗(原代地鼠肾细胞) 血清学效果 META分析 

分 类 号：R186[医药卫生—流行病学]