北京市男男性行为人群队列随访中高危行为变化的调查研究  

High risk behavior changes in the follow-up of the prospective cohort study among MSM in Beijing

作　　者：张政[1] 李清春[2,3] 李书明[1] 周振海[2,3] 李东亮[1] 罗凤基[1] 杨烨[1] 梁红元[3] 阮玉华[2] 邵一鸣 

机构地区：[1]北京市朝阳区疾病预防控制中心,北京100021 [2]中国疾病预防控制中心性病艾滋病预防控制中心,北京100050 [3]北京协和医学院公共卫生学院,北京100005

出　　处：《中国艾滋病性病》2009年第6期586-588,591,共4页Chinese Journal of Aids & STD

基　　金：国家自然科学基金项目(10501052);国家科技部(2007DFC30230)

摘　　要：目的了解北京市男男性行为人群队列随访中高危行为的变化情况。方法采用前瞻性队列研究,对招募的符合纳入标准的参加者每6个月随访一次,了解其行为学变化情况。应用广义估计方程(GEE)分析高危行为的变化。结果在6个月及12个月随访中,研究对象近3个月与男性群交、近3个月同性商业性性行为、近1个月与临时男性性伴无保护性肛交的发生比例均呈下降趋势,差异具有统计学意义;6个月随访与本底调查时相比,调查对象最后一次无保护性肛交的发生比例显著性下降;12个月随访与6个月随访相比,调查对象近3个月男性性伴数>1的比例有显著性下降;未见其他高危性行为的变化有统计学意义。12个月随访的队列保持率为86.2%(437/507),HIV新发感染率为2.58/100人年(95%CI:1.05～4.12)。结论综合考虑男男性行为人群HIV新发感染率和高危行为的变化情况,虽然该人群高危行为的发生比例呈一定的下降趋势,但尚需采取有效预防干预措施来控制该人群HIV的传播流行。Objective To investigate the high risk behavior changes in the follow-up of the prospective cohort study among MSM in Beijing. Methods Participants who met the screening criteria of the cohort were followed up every 6 months to investigate the behavior changes. Results At the 6-month follow-up and the 12-month follow-up visit, the number of the subjects who participated in male group sex in the past three months, had commercial sex with male sex partners in the past three months and had unprotected anal intercourse with casual male partners in the past month all decreased significantly; compared to the baseline survey, the number of the subjects who had un- protected anal intercourse in the last sex activity declined significantly at the 6-month follow-up; compared to the 6- month follow-up, the number of the subjects who had more than one male sex partners in the past three months dedined significantly; no other significant changes were observed. At the 12-month follow-up visit, 86.2% （437 of 507） of the participants remained in the cohort,and the HIV incidence was 2.58 per 100 person-years （95%CI= 1.05-4. 12） during 12-month follow-up. Conclusion Considering the HIV incidence and high risk behaviors changes in this study, though high risk behaviors declined, effective interventions should be taken to control the transmission of HIV among MSM.

关 键 词：艾滋病病毒 男男性行为者 高危行为 前瞻性队列研究 

分 类 号：R512.91[医药卫生—内科学]