乙肝疫苗免疫失败因素研究  

A research on risk factors of hepatitis B vaccinotion failure

作　　者：赵东设[1] 董雷[1] 谢海斌[1] 姚军[2] 沈毅[3] 朱海深 

机构地区：[1]温州市鹿城区疾病预防控制中心,浙江325000 [2]浙江省疾病预防控制中心 [3]浙江大学

出　　处：《中国预防医学杂志》2009年第12期1085-1087,共3页Chinese Preventive Medicine

摘　　要：目的探讨乙肝疫苗免疫失败机制。方法对全程乙肝疫苗接种后抗体检测仍为阴性者(免疫失败)进行HBVDNA检测、免疫失败者及加强免疫对照进行生活习惯等影响因素病例调查研究。结果15例对象中发现1例HBVDNA阳性;条件单因素回归分析结果表明接种对象的性别、饮酒史、身高、体重、家族史病例组与对照组之间差异有统计学意义(P<0.05),条件多因素逐步回归分析有三种因素进入回归方程,接种对象的性别、家族史、饮酒情况有差异。男性发生免疫失败的概率是女性的1.79倍,有家族史对象免疫失败的概率为无家族史对象的4.98倍,每周饮酒2两以上对象是很少喝酒对象的1.58倍。结论本研究结果表明,接种对象的微量HBV感染、性别、家族史、饮酒情况为乙肝疫苗失败的影响因素。Objective To investigate risk factors of hepatitis B vaccination failure.. Methods The people with HBV vaccination and maintaining anti-HBs negative status were examined for HBV DNA. Investigation was also performed on habits of people with failed or succeeded HBV vaccination by a case-control study. Results We examined HBV DNA for 15 HBV vaccination failure cases, in one of which the positive HBV DNA was found. In a single conditional faeor analysis, differences were significant between the case and the control groups in gender, family history, alcohol drinking history, body height and weight （ P 〈 0. 05 ）. After a multiple conditional stepwlse logistic regression analysis, there were 3 of the 5 factors selected for regression model, including gender, family history and alcohol drinking history of the vaccinated participants. The rate of vaccination failure occurrence in male is as 1.79 times as that in female, the rate of the failure in people with family history was as 4. 89 times as that in people without family histroy, the rate of the failure in people who drank the alcohol more than 100grams a week was as 1.58 times as that in people who rarely drank. Conclusion Trace virul infection, male, family history and frequent alcohol consumption are risk factors of HBV vaccination failure.

关 键 词：乙肝疫苗 HBV微量病毒感染 免疫失败 因素研究 

分 类 号：R186[医药卫生—流行病学]