红外光谱技术在医学中的应用  

The Application of Fourier Transform Infrared Technology in Biomedical Sphere

作　　者：张小青[1] 徐智[1] 凌晓锋[1] 徐怡庄[2] 吴瑾光[2] 

机构地区：[1]北京大学第三医院普通外科,北京100191 [2]北京大学化学与分子工程学院,北京100871

出　　处：《光谱学与光谱分析》2010年第1期30-34,共5页Spectroscopy and Spectral Analysis

基　　金：国家自然科学基金项目(50673005);北京市自然科学基金项目(2072020)资助

摘　　要：系统回顾了过去50余年中红外光谱技术的发展创新及在生物医学领域中的研究应用。傅里叶变换红外光谱技术已从对单个细胞水平结构构成与形态的研究进展到组织水平。现代红外光谱技术联合成熟的模式识别技术与组织微阵列技术,为平行大规模测定分子结构提供了可能。此外,红外光谱技术的临床应用为良恶性肿瘤的判别提供了可信的参考依据,并可准确判别甲状腺、乳腺、胃肠道及腮腺等组织的良恶性,具有极广泛的应用前景。The authors systemically reviewed the development of FTIR technology and its innovative advances during the past fifty years. FTIR technique was once abandoned after initial exploration in biomedical fields, which could not confirm its reliability and credibility. After technological innovation and refined numerical analysis methods, FTIR technique has been applied to a wide range of fields, from single cellular to the complex biomedical tissue components. Nowadays, mature and advanced FTIR technology, such as FTIR microspectrometer and FTIR imaging system, with the aid of pattern recognition and tissue microarray, greatly facilitated the large parallel scale investigation of molecular structure. The recent development of FTIR spectroscopic imaging has enhanced our capability to examine, on a microscopic scale, the spatial distribution of vibrational spectroscopic signatures of materials spanning the physical and biomedical disciplines. The integration of instrumentation development, theoretical analyses to provide guidelines for imaging practice, novel data processing algorithms, and the introduction of the technique to new fields. FTIR technique has helped analyze the complex components of bile stones, which persisted to be a vexing problem and causing high death rate in China. Besides, FTIR technology could provide reliable information in discriminating benign and malignancy. It has been used in detecting thyroid nodules, mammary gland, gastrointestinal tract, cardiovascular and prostate diseases, and parotid gland tissue in combination with ATR detecting device, and has broad clinical application prospects. Till now, FTIR technology has achieved the fast and accurate diagnosis for freshly dissected tissues such as discriminating thyroid carcinoma from nodular goiter intraoperatively. However, further investigations need to be done in this sphere to achieve greater accomplishments.

关 键 词：中红外光谱 生物医学诊断 组织检测 恶性肿瘤 

分 类 号：O657.3[理学—分析化学]