大血藤药材及不同提取物FTIR的比对分析  

Analysis and Comparison of Daxueteng and Their Extracts by FTIR

作　　者：尹泉[1] 李惠芬[1] 周群[2] 徐茂玲[1] 阎姝[1] 孙素琴[2] 吴咸中[3] 

机构地区：[1]天津医科大学药学院,天津300070 [2]清华大学化学系,生命有机磷化学及化学生物学教育部重点实验室,北京100084 [3]天津市中西医结合急腹症研究所,天津300100

出　　处：《光谱学与光谱分析》2010年第1期54-57,共4页Spectroscopy and Spectral Analysis

基　　金：国家科技支撑计划项目(2006BAI04A15)资助

摘　　要：采用红外光谱法(FTIR)、二阶导数红外光谱法和二维相关光谱分析技术(Two-Dimensional CorrelationSpectroscopy)对江西和安徽大血藤药材、水提物、蒽醌类提取物和残渣进行了快速无损比对分析研究,从中发现两产地大血藤药材的谱图中均出现1 400～1 620 cm^(-1)和1 000～1 200 cm^(-1)两个强峰带,说明药材含有大量的药效成分蒽醌类和糖类物质;蒽醌提取物的谱图中也有上述2个谱带,但1 400～1 620cm^(-1)谱带明显强于1 000～1 200 cm^(-1)谱峰,说明该提取工艺适宜提取蒽醌类物质;而水提物中2个谱峰带则是后者明显强于前者,证实该提取工艺适宜提取糖类物质;另外通过红外谱图和二阶导数红外谱图的对比发现在药材残渣中含有大量的草酸钙晶体。证明红外光谱技术不仅能对原药材及提取物的药效基团进行分析和指认,还能区分不同产地药材的提取物含量的高低,成功地建立了大血藤及其不同提取物药效成分比对分析的新方法。The present study is to compare and analyze Sargentodoxa cuneata （oliv） Rehd. etwils herbs, the aqueous, anthraquinone extracts and residue in Jiang Xi and An Hui quickly and undamagedly by Fourier transform infrared spectroscopy（FTIR） and two-dimensional correlation spectroscopy. In the spectra of DaXueTeng, there are two strong peak areas at about 1 400- 1 620 cm^-1 and 1 000-1 200 cm^-1, and it was concluded that DaXueTeng contains much glycoside and anthraquinone. Anthraquinone extracts only exhibit strong peaks of 1 400-1 620 cm^-1 which were stronger than that of 1 000-1 200 cm^-1 , and this illustrated that this method was adapted to extracting anthraquinone; then aqueous only show powerful peaks of 1 000-1 200 cm^-1 , so the authors know that the craftwork was suitable for extracting glycoside; finally, the authors also found that the residue of DaXueTeng contained much calcium oxalate. All of these illustrated that FTIR could not only analyze and identify traditional Chinese medicine （TCM） and extract components, but also discriminate contents of different extracts of TCM. The authors developed the new method to analyze and evaluate the DaXueTeng and their pharmacodynamic extracts successfully.

关 键 词：傅里叶变换红外光谱 大血藤 蒽醌 糖苷类 草酸钙 

分 类 号：R284.1[医药卫生—中药学]