国产及进口单唾液酸四己糖神经节苷脂治疗新生儿缺氧缺血性脑病疗效比较  

Comparison of curative effects between domestic and imported monosialotetrahexosyl ganglioside sodium on neonatal hypoxic ischemic encephalopathy

作　　者：傅大林[1] 张跃[1] 汤健[1] 赵晓科[1] 李红英[1] 杜森杰[1] 张玲[1] 袁素美[1] 高伟红 

机构地区：[1]南京医科大学附属儿童医院,210008 [2]南京油运医院

出　　处：《临床神经病学杂志》2009年第6期468-469,共2页Journal of Clinical Neurology

摘　　要：目的观察国产及进口单唾液酸四己糖神经节苷脂(GM1)治疗新生儿缺氧缺血性脑病(HIE)的疗效。方法将104例新生儿HIE随机分为申捷组(国产GM1,53例)和施捷因组(进口GM1,51例),两组在常规治疗的同时,分别给予申捷或施捷因20mg/d静脉滴注持续7～28d,观察两组的疗效及不良反应。结果两组总有效率分别为98.11%及88.24%,两组间差异无统计学意义;两组均未见明显的不良反应。结论国产及进口GM1治疗新生儿HIE均具有良好的疗效和安全性。Objective To compare the curative effects between domestic and imported monosialotetrahexosyl ganglioside sodium （GM1 ） on neonatal hypoxic ischemic encephalopathy （HIE）. Methods 104 neonates with HIE were randomly divided into Shenjie group（ domestic GM1, 53 cases ）and Phatma group （imported GM1, 51 cases）. At the basic of conventional therapy, the two groups received domestic or imported GM1 20 mg/d intravenous infusion for 7 - 28 d, rspectively. The curative effects and adverse reaction were observed. Results The total effective rates in Shenjie group and Pharma group were 98. 11% and 88.24% , respectively. There was no significant difference between the two groups. While, there was no obvious adverse reaction in the two groups. Conclusion Both the domestic and imported GM1 have the same good curative effects and safety on neonatal HIE.

关 键 词：新生儿缺氧缺血性脑病 单唾液酸四己糖神经节苷脂 

分 类 号：R722.121[医药卫生—儿科]