辽宁省建平县丙型肝炎高发病率及其流行病学特点的初步研究  

Study on high incidence of hepatitis C and its epidemiological features in Jianping county, Liaoning Province

作　　者：李宗芬 冯毅平[2] 于连政[2] 刘莉[2] 于丽娅[2] 邢立莹[2] 贺丽霞[2] 潘国伟[2] 

机构地区：[1]辽宁省建平县疾病预防控制中心,122400 [2]辽宁省疾病预防控制中心

出　　处：《中华传染病杂志》2009年第12期746-748,共3页Chinese Journal of Infectious Diseases

基　　金：基金项目：国家“十一五”科技支撑计划资助项目（2007BA107A13）

摘　　要：目的了解辽宁省建平县丙型肝炎发病率、肝硬化和肝细胞癌死亡率水平异常增高情况，初步探讨其流行病学特征。方法调用辽宁省建平县居民生命统计资料和传染病发病报告数据库资料，分析建平县23个乡镇的乙型肝炎发病率、丙型肝炎发病率、肝硬化和肝细胞癌死亡率分布特征。利用乙型肝炎发病率、丙型肝炎发病率、肝硬化死亡率和肝细胞癌死亡率进行Spearman相关分析，探讨肝炎、肝硬化和肝细胞癌的相互关系。结果2003年至2006年建平县男女肝细胞癌世界人口标准化死亡率分别为77．6／10万和22．0／10万，为辽宁省农村同期平均水平的2．0倍和1．7倍。丙型肝炎发病率为58．0／10万，为全省同期平均水平的9．5倍。丙型肝炎发病率与肝硬化死亡率（r=0．495，P=0．008）、肝硬化死亡率与肝细胞癌死亡率（r=0．646，P〈0．01）呈正相关。结论辽宁省建平县丙型肝炎发病率、肝硬化和肝细胞癌死亡率水平均显著高于辽宁省同期平均水平，亟待深入调查。Objective To investigate the significantly elevated incidence of hepatitis C and mortality of cirrhosis and hepatocellular carcinoma （HCC） in Jianping county, and to explore the epidemiological features. Methods The data from database of death registry and infectious disease surveillance in Jianping county, Liaoning Province were analyzed. The distributions of incidence of hepatitis B and hepatitis C, mortality of cirrhosis and HCC in 23 villages and towns were investigated. Spearman＇s correlation was used to explore the correlations between hepatitis, cirrhosis and HCC. Results The standardized mortality of HCC in males and females in Jianping county were 77.6/10^5 and 22.0/10^5 , respectively, which were 2. 0 and 1. 7 times, respectively of the average levels of Liaoning rural areas. The incidence of hepatitis C was 58.0/10^5 , which was 9.5 times of the average level of Liaoning Province. There were positive correlations between incidence of hepatitis C and mortality of cirrhosis （r=0.495, P=0.008）, and mortality of cirrhosis and HCC （r=0. 646, P〈 0.01）. Conclusions The incidence of hepatitis C and mortality of cirrhosis and HCC in Jianping county are significantly higher than the average levels of Liaoning Province. Further investigations of the suspected causes are needed.

关 键 词：发病率 死亡率 肝炎 丙型 肝硬化 癌 肝细胞 

分 类 号：R512.63[医药卫生—内科学] R563.9[医药卫生—临床医学]