短期吸烟对糖尿病大鼠血脂水平的影响  

Effect of short-term smoking on serum lipids levels in diabetic rats

作　　者：方丹[1] 刘红[1] 岳惠芬 邓宏明[3] 蒙碧辉[4] 温中薇[4] 孙晓菲[4] 

机构地区：[1]广西医科大学第一附属医院老年内分泌科,南宁530021 [2]广西肿瘤研究所 [3]广西医科大学第一附属医院代谢糖尿病中心 [4]广西医科大学第一附属医院内分泌科

出　　处：《中华内分泌代谢杂志》2009年第6期641-643,共3页Chinese Journal of Endocrinology and Metabolism

基　　金：广西自然科学基金（桂科自0832137）

摘　　要：高糖高脂喂养联合链脲佐菌素诱导糖尿病大鼠模型，给予8或12周被动吸烟，检测大鼠血脂变化。结果显示糖尿病吸烟组总胆固醇、甘油三酯、低密度脂蛋白胆固醇、空腹胰岛素、游离脂肪酸升高，高密度脂蛋白胆周醇下降（均P〈0．05）。停止吸烟4周后总胆固醇、甘油三酯、低密度脂蛋白胆固醇、空腹胰岛素、游离脂肪酸下降（均P〈0．01），与糖尿病对照组比较差异无统计学意义（均P〉0．05）。提示吸烟可能与血脂紊乱及胰岛素抵抗之间有密切的联系，而戒烟在一定程度上可逆转吸娴带来的危害。Diabetic rat models were induced by high-glucose and high-fat feeding combined with streptozotocin. Serum lipids were determined after 8- or 12-week passive smoking and during smoking cessation. Total cholesterol, triglycerides, low-density lipoprotein-cholesterol, fasting insulin, and free fatty acids were increased in smoking groups （ all P〈0.05 ） ; while decreased 4 weeks after smoking cessation （ vs control group, all P〉0.05）. High-density lipoprotein-cholesterol was decreased in smoking groups （all P〈0.01 ）. The results suggested that smoking may play a role in dyslipidemia and insulin resistance of diabetic rats, and cessation of smoking may partly reverse the impact.

关 键 词：吸娴 糖尿病 实验性 大鼠 WISTAR 血脂 

分 类 号：R587.1[医药卫生—内分泌] R163[医药卫生—内科学]