酒精联合高脂饮食对大鼠胰岛素敏感性的影响及其分子机制  

Combined effects of alcohol and high-fat diet on insulin sensitivity in rats and its molecular mechanisms

作　　者：孙璇[1] 赵立娜[1] 徐肇明 彭晓琳[1] 郝丽萍[1] 孙秀发[1] 

机构地区：[1]华中科技大学同济医学院公共卫生学院营养与食品卫生学系,武汉430030 [2]深圳市人发医院血液内科

出　　处：《中华内分泌代谢杂志》2009年第6期644-645,共2页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金（30300282）

摘　　要：研究酒精和高脂对大鼠胰岛素敏感性的影响。测大鼠血糖、血胰岛素和葡萄糖转运蛋白4（GLUT-4）mRNA及蛋白表达水平。结果示各剂量组血糖、胰岛素抵抗指数升高（均P〈0．05），GLUT-4mRNA及蛋白表达显著降低（均P〈0．05）。To investigate the combined effect of alcohol and high-fat on insulin sensitivity. Fasting plasma glucose, plasma insulin of rats were measured, and glucose transportor-4 （GLUT-4）mRNA and protein were analysed. Compared with the control group, fasting plasma glucose and homeostasis model assessment for insulin resistance （HOMA-IR） were increased in other groups, GLUT-4 mRNA and protein expression levels were decreased（ all P〈0.05 ）.

关 键 词：稳态模型评估的胰岛素抵抗指数 葡萄糖转运子4 胰岛素抵抗 

分 类 号：R587.1[医药卫生—内分泌] R589.2[医药卫生—内科学]