麻醉状态下WHBE兔的心电图观测  

Determination and Analysis of Electrocardiogram in Anesthetized WHBE Rabbits

作　　者：陈亮[1] 潘永明[1] 陈民利[1] 张利棕[1] 徐孝平[1] 应华忠[1] 

机构地区：[1]浙江中医药大学动物实验研究中心／比较医学研究中心,杭州310053

出　　处：《实验动物与比较医学》2009年第6期419-423,共5页Laboratory Animal and Comparative Medicine

基　　金：浙江省公共科技基础平台项目（Dwpt-bz-12）;浙江省卫生高层次创新人才培养工程项目

摘　　要：目的探讨WHBE兔作为实验性心电图观察的应用前景。方法取成年WHBE兔、日本大耳白兔和青紫兰兔，经戊巴比妥钠溶液耳静脉注射麻醉后固定，应用多道生理记录仪描记了实验兔的心电图。结果WHBE兔心电图的基本波形与人类相似，均为窦性心律。其心率较快，288．89±28．14次／min；P波通常出现在T波的降支上；其Q—T间期，K值较日本大耳白兔和青紫兰兔小；心电轴为40．00±36．93度。结论WHBE兔胸导联的波形明显而有规律，所测得的电压比较高，因此胸导联在临床上实际意义较大，提示它适于做临床心电图的实验研究。Objective To investigate whether the WHBE rabbit was suitable for experimental electrocardiographic observation. Methods The adult 12 WHBE rabbits, 7 Japanese white rabbits and 6 Chinchilla rabbits were anesthetized by sodium amylobarbitone （30 mg/kg） and the electrocardiograms （ECG） of the rabbits were recorded by multi-channel physiological recorder. Results The basic wave pattern of the EGG of WHBE rabbit was similar to that of human being. Heart rhythm of WHBE rabbit was sinus original. Owing to the fast heart rate of WHBE rabbit （288.89±28.14 beats per minute, bpm）, the P-wave of the WHBE rabbit ECG usually occurred on the descending branch of T-wave. The Q-T interval and K-value of the WHBE rabbits were both lower than those of Japanese white rabbits and Chinchilla rabbits. The range of the ECG axis in WHBE rabbits （40.00±36.93 degrees） were changed greatly. Conclusion The shapes of waves in chest leads of WHBE rabbit are obvious and regular. The recorded voltage was higher. So the ECG in chest leads is more available for the clinical analysis, and WHBE rabbits would be more suitable as a new kind of laboratory animals for electrocardiographic experimental studies.

关 键 词：WHBE兔 心电图 

分 类 号：Q95-33[生物学—动物学]