运用响应曲面法优化核黄素磷酸钠海藻酸钙胃漂浮微球  

Optimization of riboflavin sodium phosphate loading to calcium alginate floating microspheres by response surface methodology

作　　者：张安阳 范田园[1] 

机构地区：[1]北京大学药学院药剂学系,北京100191

出　　处：《北京大学学报（医学版）》2009年第6期682-686,共5页Journal of Peking University:Health Sciences

摘　　要：目的:考察核黄素磷酸钠胃漂浮缓释微球的制备、优化和体外性质。方法:采用离子胶凝-烘干法制备了核黄素磷酸钠海藻酸钙胃漂浮缓释微球。结果:考察了微球的外观、包封率、漂浮性能和体外释放,并运用响应曲面法分析、优化了微球处方。结论:优化后的微球外观圆整,包封率为57.49%,体外漂浮8小时以上,释放符合F ick扩散方程。Objective：To investigate the preparation,optimization and in vitro properties of riboflavin sodium phosphate floating microspheres.Methods： The floating microspheres composed of riboflavin sodium phosphate and calcium alginate were prepared using ion gelatin-oven drying method.Results： The properties of the microspheres were investigated,including the buoyancy,release,appearance and entrapment efficiency.The formulation was optimized by response surface methodology（RSM）.Conclusion： The optimized microspheres were round.The entrapment efficiency was 57.49%.All the microspheres could float on the artificial gastric juice over 8 hours.The release of the drug from the microspheres complied with Fick＇s diffusion.

关 键 词：胃肠道 迟效制剂 藻酸盐 黄素单核苷酸 工艺学 制药 

分 类 号：R944.9[医药卫生—药剂学]