光老化性疾病皮损中c-jun、c-fos的表达及意义  

Expression of c-jun and c-fos in Skin Lesion of Photoaged Disease

作　　者：郭碧蓉[1] 刘平[1] 马毳毳[1] 任建文[1] 王香兰[1] 

机构地区：[1]西安交通大学第二附属医院皮肤科,陕西西安710004

出　　处：《中国皮肤性病学杂志》2009年第12期790-792,共3页The Chinese Journal of Dermatovenereology

基　　金：国家自然科学基金资助项目(30600764)

摘　　要：目的研究原癌基因c-jun、c-fos在光老化性疾病皮损中的表达,探讨c-jun、c-fos在光老化性疾病发病中的作用机制。方法应用免疫组化法检测c-jun、c-fos蛋白在正常组织、光老化性疾病皮损组织中表达。结果光老化性疾病皮损组织c-jun、c-fos蛋白表达高于其在正常对照组皮肤组织中的表达,其主要表达于细胞核,少数定于细胞浆;相关分析显示光老化性疾病皮损组织c-jun与c-fos之间呈正相关;不同类型光老化性疾病即慢性光化性皮炎、光化性弹性纤维病、日光性角化病皮损中c-jun、c-fos的表达无统计学差异。结论c-jun、c-fos表达异常可能共同参与光老化性皮肤病的发生、发展,但与光老化性疾病的临床类型无关。Objective To detect the expression of c-jun and c-fos protein in skin lesion of photoaged disease and investi- gate the role of c-jun and c-fos in the pathogenesis of photoaged disease. Methods c-jun and c-fos protein expression was examined by immunohistochemistry in normal skin tissues, lesional photoaged disease skin of different types. Results The expression of c-jun and c-fos in the photoaged disease was higher than that of in normal skin, c-jun and c-fos was located in both cytoplasma and nuclei, locating in nuclei of many cells and in cytoplasma of few cells. An positive correlation was found between c-jun and c-jun in photoaged disease. The expression of c-jun and c-fos in chronic actinic dermatitis, actinic elastosis , and solar keratosis had no difference. Conclusions c-jun,c-fos may play an important role in the pathogenesis and development of photoaged disease, but not relate to category of photoaged disease.

关 键 词：C-JUN C—fos 光老化性疾病 免疫组化 

分 类 号：R758.1[医药卫生—皮肤病学与性病学]