慢性乙肝患者脯氨酸肽酶与肝纤维化的关系分析  

The relationship between prolidase and liver fibrosis in chronic hepatitis B patients

作　　者：程大也[1] 

机构地区：[1]中国医科大学附属第一医院输血科,辽宁沈阳110001

出　　处：《胃肠病学和肝病学杂志》2009年第12期1114-1116,共3页Chinese Journal of Gastroenterology and Hepatology

基　　金：辽宁省教育厅2008年度高等学校科研项目基金资助(2008752)

摘　　要：目的了解血清脯氨酸肽酶(prolidase,PLD)与乙型病毒性肝炎肝纤维化程度的关系。方法测定191例乙型肝炎患者血清中PLD水平,利用ROC曲线分析ALT、AST、AST/ALT和PLD的面积,判断PLD的最优截断点并计算不同标准的灵敏度、特异度、阳性预测值(PPV)、阴性预测值(NPV)、Youden指数。结果慢性乙型肝炎患者PLD值随着肝纤维化严重程度升高,S2-4期(明显肝纤维化)明显高于S0-1期(无明显肝纤维化)(P<0.01)。ALT、AST、AST/ALT和PLD的ROC曲线下面积分别为0.614、0.648、0.655和0.807。PLD的最优截断点约为1 250 U/L,灵敏度和特异度分别为75.6%和75.2%。结论血清PLD测定对于慢性乙型肝炎患者肝纤维化程度判定有一定的临床价值。Objective To study the relationship between prolidase （PLD） and liver fibrosis in chronic hepatitis B patients. Methods PLD activity in serum collected from 191 patients with hepatitis B were determined. Receiver operating characteristic curve （ROC） was used to evaluate diagnostic value of PLD activity. Results PLD values of hepatitis B patients rose with liver fibrosis severity, and PLD value of S2-4 phases was higher than that of S0.1 phases （P 〈0.01 ）. The AUROC of ALT, AST, AST/ALT and PLD were 0. 614, 0. 648, 0. 655 and 0. 807, respectively. The optimal cutoff value of PLD was 1 250 U/L. Sensitivity and specificity were 75.6% and 75.2% , respectively. Conclusion PLD is a potent marker for assessing liver fibrosis stages in chronic hepatitis B patients.

关 键 词：慢性乙型肝炎 脯氨酸肽酶 肝纤维化 

分 类 号：R512.62[医药卫生—内科学]