36例万古霉素临床应用分析  

Analysis of ClinicalApplication of Vancomycins in 36 Cases

作　　者：周黎[1] 邢卫[1] 

机构地区：[1]苏州市市立医院,江苏苏州215004

出　　处：《抗感染药学》2009年第4期270-273,共4页Anti-infection Pharmacy

摘　　要：目的:分析万古霉素血药峰谷浓度及病原学药敏检测情况。方法:采用回顾性调查方法随机提取2008年1月-2009年4月期间使用万古霉素治疗并进行血药峰谷浓度监测以及病原学药敏试验的36份病历进行分析。结果:万古霉素治疗有效率为75.00%(27/36),治疗药物监测平均谷浓度为(22.87±15.93)μg/mL。其中17例测定谷及峰值,平均血药峰浓度为(38.69±19.94)μg/mL。对万古霉素敏感菌株为金黄色葡萄球菌(MRSA)、表皮葡萄球菌(MRSE)、耳葡萄球菌、溶血性葡萄球菌、屎(粪)肠球菌、G+杆菌。结论:应加大万古霉素血药浓度监测与病原学药敏试验的力度,根据血药浓度监测与病原学药敏试验结果及时调整万古霉素的用量。Objective： To analyze the peak and valley of blood concentration treated by vancomycin and etiological drug sensibility testing. Methods： Using retrospective analysis method, selecting 36 cases randomly from 2008 January to 2009 April which were treated with vancomycin, monitoring the peak and valley of blood concentration and the etiological drag sensibility testing. Results： patients who took vancomycin had an effective rate of 75.00%（27/36）, therapeutic drug monitoring for the valley of average blood concentration was （22.87± 15.93） μg/mL, among them, valley of blood concentration corresponding the peak in 17 cases, the peak of average blood concentration was （38.69±19.94） μg/mL and the sensitive st-rains of vancomycin were vancomycin-resistant Staphylococcus aureus（VRSA）, vancomycin-resistant Staphylococcus epiderrnidis（VRSE）, Staphylococcus auricularis, Hemolyn＇c streptococcus, Enterococcus faecium（faecalis）, Gram-positive bacilli. Conclusion： Clinical practice should strengthen blood concentrations of vancomycin monitoring, and adjust vancomycin exposure leels, according to the results of therapeutic drug monitoring and etiological drug sensibility testing.

关 键 词：万古霉素 临床应用 血药浓度 药敏试验 

分 类 号：R978.1[医药卫生—药品]