茂名地区1984例药品不良反应报告分析  

Analysis of 1 984 Adverse Drug Reaction Reports in Maoming Area

作　　者：林焕泽[1,2] 杨华[1] 陈建华[1] 吴秀荣[1] 廖景辉 吴明东[1] 李晖[1] 

机构地区：[1]茂名市人民医院,广东茂名525000 [2]茂名市食品药品监督管理局,广东茂名525000

出　　处：《抗感染药学》2009年第4期282-284,共3页Anti-infection Pharmacy

基　　金：茂名市科技计划项目(编号:2007111)

摘　　要：目的:通过对2007年1月-2008年12月茂名地区各医疗单位呈报的1984例药品不良反应(ADRs)报告进行分析,了解茂名地区ADR发生与分布情况。方法:采用Excel电子表格和手工筛选方法,将药品分类、ADR临床表现与分类、给药途径及处理结果等建立ADR数据库。结果:1984例的ADR报告中,药品种类排首位的是抗菌药物有1164例,占51.96%,其次是中药制剂(包括中成药)有456例,占20.36%,排列第3位的是电解质、酸碱平衡及营养药有158例,占7.01%。ADR涉及的药品种类,头孢菌素类占45.10%(525/1164)、喹诺酮类占15.81%(184/1164)、青霉素类占11.77%(137/1164)。结论:发生ADR药物以抗感染药物最多,ADR涉及的系统与器官以皮肤及其附件损害最多,静脉注射药物发生的ADR最高。Objective： To find out the occurrence and distribution of ADR of Maoming area, we analyse 1 984 cases of adverse drug reaction（ADRs） reports that Maonting area medical units reported from January 2007 to December 2008. Methods： Using Excel spread sheets and manual screening methods, we established the ADR database that contained the classification of drugs,the clinical manifestations and classification of ADR, the route of administration and the results. Results： In the 1 984 cases of ADR related drugs, antibiotics occupy the first place, 1 164 cases use it, and it accounted for 51.96%. Chinese materia medica preparation（including Chinese patent drug） occupy the second place, 456 cases use it ,and it accounted for 20.36%, electrolytes, pH balancing regulator and nutrition occupy the third place, 158 cases use them, and they accounted for 7.01%, The constitution of ADR related drugs： 45.10%（525/1 164） were cephalosporins, 15.81%（184/1 164） were quinolones, 11.77%（137/1164） were penicillins. Conclusion： Among the drugs that may cause ADR, anti-infectives are the maximum; among the systems and organs that involved in ADR, the most damaged ones are the skin and its annexes; intravenous drug is the most likely to have ADR.

关 键 词：药品不良反应 茂名地区 合理用药 

分 类 号：R969.3[医药卫生—药理学]