薄膜-超声分散法制备川芎嗪固体脂质纳米粒  

Preparation of ligustrazine solid lipid nanoparticles by film-ultrasonic wave dissolving techniques

作　　者：饶卫兵[1,2] 郝存江[1] 魏丽[1] 李发萍[1] 

机构地区：[1]天津中医药大学 [2]天津市中药化学与分析重点实验室,天津300193

出　　处：《天津中医药》2009年第6期503-505,共3页Tianjin Journal of Traditional Chinese Medicine

摘　　要：[目的]制备川芎嗪固体脂质纳米粒,并对其载药量和包封率进行考察。[方法]采用薄膜超声分散法制备,并以包封率为指标采用正交设计法优化川芎嗪固体脂质纳米粒的制备工艺。[结果]所得川芎嗪固体脂质纳米粒的最佳制备处方是川芎嗪30mg,卵磷脂300mg,硬脂酸300mg,30g/L的甘露醇15mL。[结论]该处方可用于川芎嗪固体脂质纳米粒的制备,工艺简单、可行。[Objective] To prepare the ligustrazine solid lipid nanoparticles and investigate its entrapment efficiency and drug loading. [Methods] The ligustrazine solid lipid nanoparticles were prepared by film ultrasonic wave dissolving techniques. The optimum formula was selected through orthogonal design test according to the entrapment efficiency. [Results] The optimizing technique was using ligustrazine （30 mg）,stearic acid （300 mg）,lecithin （300 mg）,mannitol （30g/L,15 mL）. [Conclusion] The preparation technology of ligustrazine solid lipid nanoparticles by film ultrasonic wave dissolving technique is feasible.

关 键 词：川芎嗪固体脂质纳米粒 薄膜超声分散法 制备 

分 类 号：R917[医药卫生—药物分析学]