反向疫苗学及其筛选保护性抗原应用进展  

The Development of Reverse Vaccinology and Its Application for Protective Antigen Screening

作　　者：宋振威[1] 周学章[1] 王玉炯[1] 

机构地区：[1]宁夏大学西部特色生物资源保护与利用教育部重点实验室,银川750021

出　　处：《世界科技研究与发展》2009年第6期989-992,999,共5页World Sci-Tech R&D

基　　金：国家"973"计划项目子课题2006CB504401;2008年宁夏科技攻关项目

摘　　要：近年发展起来的反向疫苗学,是现代疫苗学研究的一种新策略,使疫苗学研究进入了一个新时期。这种以"序列-结构-功能"思想为依据,以免疫信息学、计算机预测设计以及高通量的各种组学(包括基因组学、转录本组学、蛋白质组学等)综合集成技术为核心的策略,能为各种病原体保护性抗原候选分子的发现提供一条新途径,可以提高疫苗筛选效率。The rapidly-developed reverse vaceinology was a new strategy on the modern study of vaccinolog）,whieh marked a turning point. Based on the principle of ＂ sequence-structure-function＂, the strategy, raked immunization information science, computer prediction design and high-throughput of the various groups （ including genomics, transcription of this group, proteomics and so on） as its core. It was hoped that the strategy can give new lights to find more protective antigen of pathogen as the candidates to produce vaccine, and improve our efficiency to vaccine screening.

关 键 词：反向疫苗学 保护性抗原 筛选 

分 类 号：R392[医药卫生—免疫学]