螺旋藻多糖调节小鼠免疫功能的作用  

Immune-regulatory Effects of Spirulina Polysaccharide on Mice

作　　者：韦金河[1] 虞利俊[1] 唐玉邦[1] 裴勤[1] 韩建明[1] 王恒义[1] 

机构地区：[1]江苏省农业科学院原子能农业利用研究所,江苏南京210014

出　　处：《江苏农业学报》2009年第6期1351-1353,共3页Jiangsu Journal of Agricultural Sciences

摘　　要：为研究螺旋藻多糖对小鼠免疫功能的调节作用,将螺旋藻多糖分别以低剂量6.7 mg/kg(推荐的人体每日摄入量)、中剂量67.0 mg/kg和高剂量134.0 mg/kg连续饲喂受试小鼠15 d后,对小鼠进行免疫调节试验。结果表明:螺旋藻多糖在134.0 mg/kg剂量时,可明显增强二硝基氟苯(DNFB)所致的小鼠迟发性超敏反应(P<0.05);中、高剂量组小鼠的胸腺指数、高剂量组小鼠血清的半数溶血值(HC_(50))及小鼠的单核-巨噬细胞吞噬指数明显高于对照组(P<0.05),且有明显的剂量-反应关系。根据保健食品免疫调节作用评价标准,螺旋藻多糖具有免疫调节作用。To study the immune-regulatory effects of spirulina polysaccharide（SP） on mice, the different dosage of spirulina polysaccharidc（6.7 mg/kg,67.0 mg/kg, 134.0 mg/kg） was taken to feed mice for 15 d. When the dosage of spirulina polysaccharide was 134. 0 mg/kg, the delayed-type hypersensitivity（DTH） of mice induced by dinitrofluorobenzene （DNFB） was significantly inhibited （P〈0. 05 ）, thymus index of mice in middle-dose group（67.0 mg/kg）and high-dose group（ 134. 0 mg/kg） that in were significantly higher than control, HCs0and phagocytosis index of mice in high-dose group were significantly higher than that in control （ P〈0. 05 ） , showing apparent dose-effect relation. According to the evaluation standard of immune-regulatory of health food, the results indicate that spirulina polysaceharide have the immune-regulatory functions.

关 键 词：螺旋藻多糖 小鼠 调节 免疫功能 

分 类 号：R285.5[医药卫生—中药学]