基于母体血浆胎盘源及胚胎源核酸分子的早期妊娠诊断及早期胎儿性别鉴定技术  

Early Pregnancy Diagnosis and Early Prenatal Sex Determination by Maternal Plasma Cell-free Nucleic Acids from Placenta or Fetus

作　　者：邢光东[1,2] 夏银[3] 茆骏[2] 郭宁[2] 王根林[2] 

机构地区：[1]江苏省农业科学院畜牧研究所,江苏南京210014 [2]南京农业大学动物科技学院,江苏南京210095 [3]哈佛大学医学院麻省总医院系统生物学研究中心,美国麻萨诸塞州波士顿02114

出　　处：《江苏农业学报》2009年第6期1420-1422,共3页Jiangsu Journal of Agricultural Sciences

基　　金：江苏省农业科技自主创新基金[CX(09)638]

摘　　要：动物早期妊娠诊断及早期胎儿性别鉴定是繁殖技术中的关键技术。奶牛早期妊娠诊断可及时消除配种后假孕、妊娠后假发情等不利因素,胎儿性别早期鉴定可提高母牛犊的出生比例。近年来,随着孕妇血浆/血清中的胎儿源性游离DNA及胎盘源性游离RNA的发现,使人的早期性别鉴定技术及产前早期诊断技术的研究取得突破性进展;同时也使胎盘特异性表达基因的无创伤性研究成为可能。这些均为单胎动物,特别是奶牛的早期妊娠诊断及早期性别鉴定技术提供了理论依据及技术支持。Early pregnancy diagnosis and early prenatal sex determination are key issues in animal reproduction, which remain to be fully addressed. Early pregnancy diagnosis in cows can prevent pseudopregnancy and false heat, while early sex determination can increase proportion of cows. Since the recent identification of cell-free fetal DNA and placental RNA in serum or plasma of pregnant women, great progresses have been made toward development of new techniques for prenatal cxanlination and sex determination, and noninvasive early pregnancy diagnosis of transcripts specifically expressed by the placenta. All these advances provide intriguing perspectives for early pregnancy diagnosis and early sex determination in cows.

关 键 词：动物 游离胎儿核酸分子 早期妊娠诊断 早期性别鉴定 

分 类 号：S814.1[农业科学—畜牧学]