新生儿低氧缺血性脑病早期肾损伤敏感指标的研究  

Early time kidney damage sensitive target research on Newborn with hypoxic-ischemic encephalopathy

作　　者：文仕清[1] 焦德清[2] 伍心莲 

机构地区：[1]罗江县人民医院儿科,四川罗江618500 [2]广元市中心医院,四川广元628000

出　　处：《四川医学》2009年第12期1941-1942,共2页Sichuan Medical Journal

摘　　要：目的探讨新生儿低氧缺血性脑病早期肾损伤敏感指标,为早期干预提供理论依据。方法以2005年1月-2007年12月我院新生儿病房的65例新生儿缺氧缺血性脑病以及同期我院产科出生的38名健康儿童为研究对象,查尿β2-MG、α1-MG、ALB和血β2-MG。结果试验组与对照组比较,尿β2-MG、α1-MG、ALB和血β2-MG明显升高（P〈0.05）,差异有统计学意义。结论尿β2-MG、α1-MG、ALB和血β2-MG为HIE患儿早期肾损伤敏感指标,HIE患儿早期机体反应轻时已经存在肾损害并且病变累及肾小球和肾小管。Objective To investigate early time kidney damage sensitive target on newborn with hypoxic-ischemic encephalopathy. Provides the theory basis newly for the early intervention. Methods I courtyard newborn hospital ward＇s 65 example newborn with hypoxic-ischemic（ hereafter refers to as HIE） take January, 2005 to December, 2007 as well as same time my courtyard obstetrics family background 38 healthy children as the object of study. Looks up hematuria β2 microballoons protein （β2-MG） ,urinatesal microballoons protein （α1-MG） ,urinates albumin （ALB）. Results The experimental group and the comparison compare, urinate β2 oMG. urinates α1-MG, ALB, blood β2-MG. elevates obviously, has the remarkable difference. Conclusion Urinates β2-MG, urinates α1-MG, ALB, blood β2-MC, is the HIE baby early time kidney damage sensitive target. HIE baby early time organism responded is light when already had the kidney harm, and the pathological change implicates the renal glomerulus and the tubulus renalis.

关 键 词：新生儿 缺氧缺血性脑病 早期肾损伤 

分 类 号：R722.1[医药卫生—儿科]