钛催化的不对称硫醚氧化研究进展  

Recent development of titanium-catalyzed enantioselective sulfoxidation

作　　者：唐红艳[1] 曾庆乐[1] 

机构地区：[1]成都理工大学材料与化学化工学院,四川成都610059

出　　处：《化工科技》2009年第6期58-63,共6页Science & Technology in Chemical Industry

基　　金：国家自然科学基金资助项目(20672088)

摘　　要：手性亚砜是重要的手性中间体和辅剂、手性配体和催化剂、手性药物。手性亚砜可以采用生物方法和化学方法来合成,化学方法包括手性辅剂诱导、手性氧化剂氧化、手性拆分和不对称催化等。手性金属络合物催化硫醚的不对称氧化是合成手性亚砜最有效的方法。理性设计各种手性金属络合物催化剂应用于催化对映选择性氧化潜手性硫醚反应中,近年来引起了化学家们较大的关注。作者简要综述了钛络合物催化剂在不对称硫醚氧化反应制备手性亚砜中的应用。Chiral sulfoxides and their derivatives are important chiral intermediates and auxiliaries, chiral ligands and cata chemical methods. The lys eh ts, and chiral drugs. Chiral sulfoxides may be obtained by biological and emical methods include chiral auxiliary＇s induction , chiral oxidant＇s oxidation,chiral resolution,and enantioselective catalysis. The most efficient way to generate chiral sulfoxides is asymmetric oxidation of prochiral sulfides catalyzed by chiral metal complexes. Recently, the rational design of chiral metal complexes for enantiomerically catalytic oxidation of sulfides attracts much attention. Applications of titanium-catalyzed enantioselective sulfoxidation to sulfoxide are reviewed in this paper.

关 键 词：手性亚砜 钛络合物 硫醚 

分 类 号：O621.34[理学—有机化学] O622.7[理学—化学]