系统性红斑狼疮患者血清CA125的测定及其临床意义  

Determination and Clinical Significance of Serum CA125 in Patients with Systemic Lupus Erythematosus

作　　者：张胜桃[1] 周逸婵[1] 朱琳[1] 沈桂芬[1] 何培根[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院风湿科,武汉430030

出　　处：《华中科技大学学报（医学版）》2009年第6期844-846,共3页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

摘　　要：目的了解系统性红斑狼疮(SLE)患者血清肿瘤标记物CA125的含量变化及其阳性率,探讨CA125与SLE疾病活动度和浆膜腔积液的关系。方法采用化学发光微粒子免疫分析法检测37名SLE患者血清CA125水平,收集患者临床资料和实验室检查结果,统计SLE患者CA125阳性率,分析其升高与SLE疾病活动度和浆膜腔积液的关系。结果全部SLE患者血清CA125阳性率为32.4%(12/37),其中活动期患者阳性率为33.3%(8/24),缓解期患者为30.8%(4/13),活动期与缓解期患者间CA125阳性率差异无统计学意义(P>0.05),伴有腹水、胸水的患者CA125的阳性率显著高于不伴腹水、胸水的患者(P<0.05)。结论CA125在SLE患者中有较高的阳性率,其升高可能与浆膜渗出有关而与病情活动无关。Objective To investigate the positive rate and concentrations of tumor marker CA125 in sera of patients with systemic lupus erythematosus（SLE）,and to analyze the relationship between serum CA125 and SLE disease activity index（SLEDAI）,and serous cavity effusion.Methods The tumor marker CA125 in sera of 37 patients with SLE was determined by means of chemiluminescent microparticle immunoassay.The clinical data and results of laboratory examination were collected.The positive rate of serum CA125,and the relationship between serum CA125 and SLEDAI,and serous cavity effusion was statistically analyzed.Results The positive rate of tumor marker CA125 in sera of SLE patients was 32.4%（33.3% in active stage,and 30.8% in remission stage,respectively,P〉0.05）.The concentration of CA125 in sera of patients with peritoneal effusion or pleural effusion was higher than in those without peritoneal effusion or pleural effusion（P〈0.05）.Conclusion The positive rate of CA125 in sera is high in SLE pa多tients,which may be related to the serous cavity effusion,but not to the activity of the SLE.

关 键 词：红斑狼疮 系统性 CA125 浆膜腔积液 

分 类 号：R593.241[医药卫生—内科学]