糖脂清对四氧嘧啶糖尿病小鼠糖、脂代谢的影响  

Effect of tangziqing on lipid metabolism in mice with diabetes mellitus induced with alloxan

作　　者：李玉红[1] 张德芹[1] 刘虹[1] 王茜[1] 李俊青[1] 

机构地区：[1]天津中医药大学中医药研究院,天津市中药药理学重点实验室,方剂学教育部重点实验室,300193

出　　处：《天津中医药大学学报》2009年第4期185-187,共3页Journal of Tianjin University of Traditional Chinese Medicine

基　　金：科技部国际合作项目资助;项目名称:治疗糖尿病组分中药的联合开发(2009DFA3107);国家科技重大专项"重大新药创制"项目资助;项目名称:组分配伍新药"三叶糖脂清片"临床前研究(2009ZX09102-128)

摘　　要：[目的]探讨糖脂清降糖、调脂的药理作用,为临床用药提供实验依据。[方法]小鼠一次性腹腔注射2%四氧嘧啶溶液200mg/kg,72h后检测空腹血糖(FBG),以空腹血糖大于11mmol/L为模型成功。糖脂清8、4、2g生药/kg连续灌胃给药30d,以二甲双胍片为对照药,观察糖脂清对小鼠空腹血糖、血脂等的影响。[结果]糖脂清可以改善四氧嘧啶糖尿病小鼠生长状况,降低四氧嘧啶糖尿病小鼠空腹血糖、血清甘油三酯(TG)含量,减轻胰腺、肝脏的病理变化。[结论]糖脂清对四氧嘧啶糖尿病小鼠有很好的治疗作用。[Objective] To explore the pharmacologic effect of Tangzhiqing for decreasing sugar and regulating lipid to provide a experimental evidence for the clinical application. [Methods] The 2% solution of alloxan,200 mg/kg,was injected into mice intraperitoneally to induce the onset of diabetes mellitus. Fasting blood glucose （FBG） was measured 72 h later. More than 11 mmol/L was taken as the success criteria of model establishing. Taking metformin as the control the effect of Tangzhiqing on the fasting blood glucose and the blood lipid was observed after 30 days for serial intragastric infusion of the drug with 8,4 and 2 g /kg of crude drug. [Results] Tangzhiqing could improve the developmental condition of the mice with diabetes mellitus,decrease the FBG and serum triglyceride （TG） in these mice,ameliorate the pathologic change of pancreas and liver. [Conclusion] Tanghiqing has good thera-peutic effect on mice with diabetes mellitus induced with alloxan.

关 键 词：四氧嘧啶 糖尿病小鼠 糖脂清 糖脂代谢 

分 类 号：R561[医药卫生—呼吸系统]