昆虫抗药性靶标不敏感机制的研究进展  

PROGRESS IN TARGET-INSENSITIVE MECHANISM OF INSECT RESISTANCE TO INSECTICIDES

作　　者：李显春[1] 王荫长[1] 

机构地区：[1]南京农业大学植保系,南京210095

出　　处：《昆虫学报》1998年第4期417-425,共9页Acta Entomologica Sinica

摘　　要：This paper reviews the current progress of target-insensitive mechanisms (AChE, sodium channel, GABA receptor) of insect resistance to insecticides. The resistant mechanism of AChE to organophosphates and carbamates is a multiple-point mutation in AChE structure gene, resulting in several insensitive AChE isoenzymes. Similarly, the resistant mechanism of GABA receptor to γ-BHC and cyclodiene insectide is one conservative point mutation in receptor structure gene involving a serine to alanine substitution (302), resulting in an insensitive receptor. As for Na+ channel, a point mutation in structure gene has been found, but whether is it universal and is the gene expression of Na+ channel involved in pyrethroids and DDT resistance remain to be clarified.This paper reviews the current progress of target-insensitive mechanisms (AChE, sodium channel, GABA receptor) of insect resistance to insecticides. The resistant mechanism of AChE to organophosphates and carbamates is a multiple-point mutation in AChE structure gene, resulting in several insensitive AChE isoenzymes. Similarly, the resistant mechanism of GABA receptor to γ-BHC and cyclodiene insectide is one conservative point mutation in receptor structure gene involving a serine to alanine substitution (302), resulting in an insensitive receptor. As for Na+ channel, a point mutation in structure gene has been found, but whether is it universal and is the gene expression of Na+ channel involved in pyrethroids and DDT resistance remain to be clarified.

关 键 词：昆虫 抗药性 靶标不敏感 机制 

分 类 号：S481.4[农业科学—农药学]