O,O-二乙基-N-[2-(3-乙酰基-2,2-二甲基-环丁基)-乙酰]硫代磷酰胺合成及杀虫活性研究  

Synthesis of O,O-Diethyl-N-[2-(3-acetyl-2,2-dimethyl-cyclobutyl)-aceto]thiophosphoramidate and Its Insecticidal Activity

作　　者：赵文浩[1,2] 梁宏艳[1] 陈海燕[1] 周红[1] 林翠梧[1] 

机构地区：[1]广西大学化学化工学院,南宁530004 [2]广西化工研究院,南宁530001

出　　处：《有机化学》2009年第12期2026-2029,共4页Chinese Journal of Organic Chemistry

基　　金：广西科技攻关(No.桂科攻0480005);广西大学重点科学技术研究(No.2003ZD05)资助项目

摘　　要：α-蒎烯经过氧化、酰氯化制成蒎酮酰氯,再与二乙基硫代膦酰胺反应,合成了未见报道的标题化合物7,经IR,MS,1HNMR,13CNMR等对标题化合物的结构进行了表征.测试了标题化合物对甘蓝薄翅螟的毒力及其对敌百虫的增效作用.初步生物活性测试结果表明,标题化合物与敌百虫混合对甘蓝薄翅螟有明显的增效作用,当标题化合物与敌百虫以3∶7的比例混合其增效作用最显著,共毒系数(co-toxicity oefficient,CTC)为226.The title compound, O,O-diethyl-N-[2-（3-acetyl-2,2-dimethyl-cyclobutyl）-aceto]thiophosphoramidate 7 is a new compound, which was synthesized by the reaction of a-pinene, and structurally con- firmed by IR, MS, ^1H NMR, and ^13C NMR techniques. The synergistic activity of the mixture of the title compound and trichlorfon to Crocidolomia pavonana （Fabricius） was evaluated by the method of co-toxicity coefficient （CTC）. The primarily bioassay result showed that the mixtures of the title compound and trichlorfon had significant synergism to Crocidolomia pavonana （Fabricius）, and the CTC of the mixture （3 ： 7） of the title compound and trichlorfon reached 226.

关 键 词：Α-蒎烯 蒎酮酸 硫代膦酰胺 合成 杀虫活性 

分 类 号：TQ453.22[化学工程—农药化工] TQ246.31