H^+/K^+-ATP酶抑制剂苯并咪唑类药物的分子光谱研究  

Studies on the Molecule Spectroscopy of H^+/K^+-ATPase Inhibitors Benzimidazoles

作　　者：陈晓红[1] 张倩芝[1] 陈建[1] 张卫红[1] 

机构地区：[1]中山大学测试中心,广州510275

出　　处：《光散射学报》2009年第4期325-328,共4页The Journal of Light Scattering

摘　　要：H+/K+-ATP酶抑制剂对于胃溃疡治疗具有划时代意义,我们对其中四种苯并咪唑药物的红外光谱进行分析,对药物结构与光谱特征相关性作探讨分析,研究表明药物的红外谱图指纹特征吸收提供了有关分子结构的有用信息,为药物分子的结构确定和新药物开发提供重要的依据。H＋/K＋ --ATPase inhibitors is an epoch-making druges on the treatment of gastric ulcer. Four kinds of inhibitors Pyridylsulfinylbenzimidazole druges was analysed with infrared spectroscopy and characterization relations of their structures and the vibration frequencies of their spectra was studied. The results show that the IR vibration frequencies provided the massages on the difference of structures of druges, our research is useful and valuable for pharmaceutical identification and the development of new chemical compound.

关 键 词：红外光谱 H+/K+-ATP酶抑制剂 苯并咪唑类药物 

分 类 号：R975[医药卫生—药品] O651[医药卫生—药学]