上海地区汉族人5-HT2a受体基因T102C多态性的基因频率分布  

A Study of the Distribution about Genotype and Allele Frequencies of T102C Polymorphism in the 5-HT2a Receptor Gene in Chinese Han Population in Shanghai

作　　者：罗星光[1,2] 江三多[1,2] 江开达[1,2] 顾牛范 林嗣萃[1,2] 钱伊萍 

机构地区：[1]上海医科大学精神医学教研室 [2]上海市精神卫生研究所遗传室

出　　处：《遗传》1998年第5期25-27,共3页Hereditas（Beijing)

摘　　要：为了揭示中国汉族人５－ＨＴ２ａ受体基因Ｔ１０２Ｃ多态性基因频率的分布，我们随机抽取了２２６例汉族健康人作研究，用限制性片段长度多态性（ＲＦＬＰｓ）技术测定研究对象的基因型和等位基因。结果发现汉族正常人５－ＨＴ２ａ受体基因Ｔ１０２Ｃ多态性基因型频率依次为：Ａ１／Ａ２＝０５０４４，Ａ１／Ａ１＝０２９６５，Ａ２／Ａ２＝０１９９１，两种等位基因频率依次为：Ａ１＝０５４８７，Ａ２＝０４５１３，杂合度Ｈ＝０５０４４、期望杂合度ｈ＝０４９５３、多态信息量ＰＩＣ＝０３７２６，表明Ｔ１０２Ｃ多态性具有合适信息，对疾病的关联研究。To investigate the distribution about genotype and allele frequencies of T102C polymorphism in the 5-HT2a receptor gene in Chinese Han population, the genotypes and alleles of 226 healthy person were examined with Restriction Fragment Length Polymorphisms(RFLPs) technique The genotype frequencies are as follows: A1/A2=0 5044,A1/A1=0 2965,A2/A2=0 1991,respectively, and the allele frequencies are as follows: A1=0 5487,A2=0 4513, respectively The heterozygosity(H) is 0 5044, the expected heterozygosity(h) is 0 4953, and the Polymorphism Information Content(PIC) is 0 3726 Our findings suggest that the T102C polymorphism in 5-HT2a receptor gene may have suitable information to be used for association study or forensic identification

关 键 词：中国汉族人 5-HT2A受体基因 T102C多态性 

分 类 号：Q987[生物学—遗传学]