巨噬细胞集落刺激因子在^(131)I治疗Graves′病中的价值探讨  

Significance of determination of the changes in serum level of macrophage colony-stimulating factor in patients with Graves' disease after radioactive iodine therapy

作　　者：李卫鹏[1] 余朝晖[2] 刘恒超[1] 孙伟莉[1] 胡永全[1] 袁媛[1] 

机构地区：[1]蚌埠医学院第一附属医院,安徽蚌埠233004 [2]安徽省蚌埠市中医院,233000

出　　处：《检验医学与临床》2009年第24期2081-2082,共2页Laboratory Medicine and Clinic

基　　金：安徽高等学校省级自然科学研究项目(KJ2009B217Z)

摘　　要：目的探讨巨噬细胞集落刺激因子(M-CSF)在131I治疗Graves′病中的价值。方法应用酶联免疫吸附试验(ELISA)法测定Graves′病患者,以及Graves′病患者131I治愈后的M-CSF水平,同时与健康人比较;分析M-CSF水平与游离甲状腺素(FT4)浓度之间的相关性。结果Graves′病患者M-CSF水平显著高于健康人,与治疗前比较差异有统计学意义(P<0.05),Graves′病患者131I治愈后的M-CSF水平呈降低,差异有统计学意义(P<0.05);M-CSF水平与FT4浓度呈正相关(r=0.58,P<0.05)。结论M-CSF可以作为131I治疗Graves′病的疗效观察指标。Objective To investigate the significance of determination of the changes in serum level of macrophage colony-stimulating factor （M-CSF） in the patients with Graves＇ disease after radioactive iodine（TM I） therapy. Methods Levels of serum M-CSF in the patients with Graves＇ disease,the cured patients treated with radioactive iodine and the health control group were measured by ELISA. The relationship between M-CSF and free thyroxine （FT4） was analyzed. Results The level of M-CSF in patients with Graves＇ disease was significantly higher than that in the heath control（P〈0. 05）,meanwhile, M-CSF in the cured patients decreased significantly（P（0.05）; and M-CSF was positively correlated with FT4 （r=0. 58,P〈0.05）. Conclusion M-CSF was a useful index to evaluate the therapeutic effect of Graves＇ disease after ^131Ⅰ treatment.

关 键 词：巨噬细胞集落刺激因子 Graves’病 游离甲状腺素 放射性碘 

分 类 号：R581.1[医药卫生—内分泌]