急性白血病患者治疗前后血清TNF-α和血浆VEGF检测的临床意义  

Clinical Significance of Determination of Serum TNF-α and Plasma VEGF Levels After Treatment in Patients with Acute Leukemia

作　　者：袁海涛[1] 吕海军[1] 李兴华[2] 

机构地区：[1]江苏省连云港市红十字中心血站,222001 [2]江苏省连云港市第一人民医院输血科,222002

出　　处：《放射免疫学杂志》2009年第6期595-596,共2页Journal of Radioimmanology

摘　　要：目的:探讨急性白血病患者治疗前后血清TNF-α和血浆VEGF水平的变化及临床意义。方法:分别应用放射免疫分析和酶联免疫法对31例急性白血病患者进行了治疗前后血清TNF-α和血浆VEGF检测,并以30名正常健康人做比较。结果:急性白血病患者治疗前血清TNF-α和血浆VEGF水平显著高于正常人组(P<0.01),经化疗和中西医结合治疗后6个月与正常人组比较仍有显著性差异(P<0.05)。结论:急性白血病的发生发展与血清TNF-α和血浆VEGF水平密切相关。Objective To explore the changes of serum TNF-α and plasma VEGF levels after treatment in patients with acute leukemia.Methods Serum TNT-α（with RIA） and plasma VEGF（with ELISA） levels were detected in 31 patients with acute leukemia before and after treatment as well as in 30 controls.Results Before treatment,the TNF-α and VEGF levels in patients were significantly higher than those in controls（P〈0.01）.After 6 months of treatment,the levels were corrected markedly but still remained significantly higher than those in the controls（P〈0.05）.Conclusion The development and clinical course of acute leukemia were closely related to the serum TNF-α and plasma VEGF levels.

关 键 词：急性白血病 肿瘤坏死因子-Α 血管内皮生长因子 

分 类 号：R442.2[医药卫生—诊断学] R733.710.7[医药卫生—临床医学]