局麻和全麻对病人血清IL-6、IL-8和M-CSF水平影响的初步探讨  

Effects of Different Types of Anaesthesia (Regional vs General) on Serum IL-6,IL-8 and M-CSF Levels in Surgical Patients

作　　者：肖加旺[1] 

机构地区：[1]江苏省连云港市第一人民医院东方医院,222042

出　　处：《放射免疫学杂志》2009年第6期602-603,共2页Journal of Radioimmanology

摘　　要：目的:探讨了局麻和全身麻醉对手术病人血清IL-6、IL-8和M-CSF水平的影响。方法:根据不同的麻醉方法将68例胃部手术病人分为硬膜外麻醉组(A组)和静吸复合全麻组(B组),每组34例。在麻醉诱导前、手术切皮和手术开始后1h抽取静脉血3ml,分别测定血清IL-6、IL-8和M-CSF浓度。结果:A组血清IL-6、IL-8和M-CSF含量在切皮和术中1h与术前比较有显著性差异(P<0.05);B组血清IL-6、IL-8和M-CSF含量无显著性差异(P>0.05);在切皮和术中1h,B组IL-6、IL-8和M-CSF含量比A组含量低(P<0.05)。结论:静吸复合麻醉能明显降低IL-6、IL-8和M-CSF浓度,有一定的临床实用价值。Objective To study the effect of anesthesia（regional vs general） on serum IL-6,IL-8 and M-CSF levels in surgical patients.Methods Serum IL-6,IL-8 and M-CSF levels were determined with RIA 3 times in 34 patients operated under ragional anesthesia and 34 patients operted under general anesthesia（both for benign gastral ulcer）.The levels were measured before induction of anesthesia,at beginning of operation and 1 hr later.Results In patients under regional anesthesia,the IL-6,IL-8 and M-CSF levels increased significantly at the beginning of operation and 1 hr later.Though dropped remained significantly higher than the levels before induction（P〈0.05）;No significant change of the levels were obsorved in patients under general anesthesia through the operation,and the levels were as a whole significantly lower than the levels under regional anesthesia（P〈0.05）.Conclusion General anesthesia（combined intravenous and inhalation） could abolish increases of serum IL-6,IL-8 and M-CSF levels during operation must be of clinical values.

关 键 词：全身麻醉 局部麻醉 白细胞介素-6(IL-6) 白细胞介素-8(IL-8) 巨噬细胞集落刺激因子(M-CSF) 

分 类 号：R581.1[医药卫生—内分泌] R392.12[医药卫生—内科学]