ACS患者动脉粥样斑块稳定性相关细胞因子变化的临床意义  

Changes of Cytokines Associated with Atherosclerotic Plaque Stability in Patients with Acute Coronary Syndrome

作　　者：徐军[1] 齐法莲[1] 王燕[1] 尹秋霞[1] 韩凝[1] 

机构地区：[1]济南军区总医院实验诊断科,250031

出　　处：《放射免疫学杂志》2009年第6期618-619,共2页Journal of Radioimmanology

摘　　要：目的:探讨急性冠脉综合征(ACS)病人血清中的细胞因子基质金属蛋白酶-1(MMP-1)、金属蛋白酶组织抑制剂-1(TIMP1)、sICAM-1、sVCAM-1水平与冠状动脉粥样硬化斑块稳定性的相关性及临床意义。方法:用ELISA检测ACS病人血清中sICAM-1、sVCAM-1、MMP-1、TIMP-1水平,并与正常对照组进行比较分析。结果:ACS组血清sICAM-1、sVCAM-1、MMP-1、TIMP-1水平均非常明显地高于正常对照组(P<0.01)。结论:外周血中sICAM-1、sVCAM-1、MMP-1、TIMP-1水平增高与ACS相关,能反映冠脉粥样硬化斑块的稳定情况,可作为评价冠状动脉粥样硬化斑块稳定性与病变严重程度的一个参考指标。Objective To investigate the correlation between serum level of relevent cytokines（Matrix metalloproteinase-1,MMP-1,Tissue inhibitor of metalloproteinase-1,TIMP1-1,Intercellular adhesion molecule-1,ICAM-1,vascular intercellular adhesion molecule-1,VCAM-1 and atherosclerotic plaque stability.Methods The serum levels of ICAM-1,VCAM-1,MMP-1 and TIMP-1 were measured with ELISA in 32 patients with ACS and 30 controls.Results Serum ICAM-1,VCAM-1,MMP-1 and TIMP-1 concentrations were significantly higher in ACS patients than those in controls（P〈0.01）.Conclusion The serum levels of ICAM-1,VCAM-1,MMP-1 and TIMP-1 might reflect the stability of atherosclerotic plaque in patients with acute coronary syndrome.

关 键 词：急性冠脉综合征 动脉粥样硬化斑块稳定性 细胞间黏附分子-1 血管细胞间黏附分子-1 基质金属蛋白酶-1 金属蛋白酶组织抑制剂-1 

分 类 号：R541.4[医药卫生—心血管疾病] R972.4[医药卫生—内科学]