空气湿度对致敏小鼠气道反应性的影响  

Influence of Relative Humidity on Methacholine-induced Airway Reactivity in Sensitized Mice

作　　者：邵有光[1] 张纬萍[2] 宋见惠[1] 郭汉身[1] 魏尔清[2] 

机构地区：[1]浙江医科大学实验动物中心,杭州310031 [2]浙江医科大学神经生物学实验室,杭州310031

出　　处：《上海实验动物科学》1998年第3期144-146,共3页Shanghai Laboratory Animal Science

摘　　要：采用镇静小鼠气道反应性测定方法，观察不同空气相对湿度下致敏小鼠对乙酰甲胆碱（MCh）的反应性。结果表明，致敏小鼠对MCh的反应性与空气湿度相关，在相对湿度较低时气道反应性高，相对湿度较高时气道反应性低。因此进行与气道反应性有关的某些实验，如小鼠哮喘实验时应注意空气湿度的影响，用本方法测试时以空气相对湿度在55％～75％时为宜。The relationship between the relative air humidity (RH) and methacholine (MCH)- induced airway reactivity was studied in sedated and ovalbumin - sensitized mice. The re- sults showed that the wheezing symptoms induced by MCH in lower RH groups were more severe than those in the higher RH groups. It is suggested that the air RH at 55%- 75% is more suitable for this testing.

关 键 词：小鼠 乙酰甲胆碱 气道反应性 空气相对湿度 

分 类 号：Q954.57[生物学—动物学] Q959.837