邻啡罗啉-Cu对DNA的损伤及其化学核酸酶活性  

Phenanthroline Cu Complex Induced DNA Damage and Its Study as a Chemical Nuclease.

作　　者：马文建[1] 曹恩华[1] 

机构地区：[1]中国科学院生物物理研究所

出　　处：《生物化学与生物物理进展》1998年第5期407-413,共7页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金

摘　　要：邻啡罗啉Ｃｕ是一种具有核酸酶活性的配合物，可产生多种形式的ＤＮＡ损伤，包括碱基修饰、异常碱基位点、链断裂及交联等．近年来，邻啡罗啉Ｃｕ因其切割核酸的性质及作为一种可产生活性氧的模型，引起了学者们浓厚的兴趣，在自由基生物学与医学及核酸化学领域受到广泛的关注．Phenanthroline Cu is a complex that have nuclease activity, it can induce several kinds of DNA damage, including base modifications, abasic sites, strand breaks and DNA protein crosslinks. There is a considerable interest on this complex in recent years in the area of free radical biology and medicine as well as nucleic acids chemistry, for the role of phenanthroline Cu as a model of generating reactive oxygen species and as a chemical nuclease.

关 键 词：邻啡罗啉-Cu 化学核酸酶 DNA损伤 活性氧 

分 类 号：Q523[生物学—生物化学]