无缝线医用OB胶粘合法吻合小肠的实验研究  

Experimmental study of the anastomosis of intestine with medical adhesive

作　　者：李建行[1] 白峰[1] 李香兰[2] 彭海军[1] 刘佳坤[1] 赵大卫[1] 

机构地区：[1]河北省胸科医院胸外科,石家庄市050041 [2]河北省胸科医院消化内科,石家庄市050041

出　　处：《河北医药》2009年第22期3028-3030,共3页Hebei Medical Journal

基　　金：河北省科学技术研究与发展攻关计划项目(编号:062761898)

摘　　要：目的探讨无缝线医用胶粘合法吻合小肠的可行性,为临床应用提供实验依据。方法20只犬随机配对分为2组,实验组采用医用OB胶粘合法吻合肠管;对照组采用传统手术方法吻合肠管。将分别测定两种吻合方法的操作时间、吻合口通畅程度、吻合口爆裂压、吻合口羟脯氨酸含量及标本组织病理学比较。结果实验组与对照组吻合口操作时间分别为(8.8±1.8)min和(18.7±3.2)min(P<0.05);术后相同时间内2组吻合口直径变化率及吻合口爆裂压测定差异无统计学意义(P>0.05);2组吻合口羟脯氨酸含量差异有统计学意义(P<0.05);实验组光镜下愈合优于对照组(P<0.05)。结论动物实验表明,结合内支架单纯应用医用胶粘合法吻合肠管,操作简便,省时,吻合口闭合严密,愈合良好,是一种切实可行的消化道吻合新方法。Objective To investigate the feasibility of the anastomosis of intestine by using medical adhesive in order to provide the experimental evidence for clinical application. Methods 20 dogs were divided into experimental group and control group. The dags in experimental group were performed with anastomosis of intestine by using medical adhesive,while the dogs in control group were treated by using traditional modus operandi. The time of two kinds of operation methods,the change rate of the anastomosis stoma diameters in different time points,the bursting pressure of the anastomosis stoma,the content of hydroxproline in the anastomosis stoma,the histopathological changes were observed and compard between the two anastomosis methods. Results The average operation time in experimental group was （8.8±1.8）min,which in control group was （18.7±3.2）min,there was a significant difference between two groups（P〈0.05）. There were no significant differences in the change rate of the anastomosis stoma diameters in different time points and the bursting pressure of the anastomosis stoma between two groups（P〉0.05）. There was a significant difference in the content of hydroxproline in the anastomosis stoma between two groups （P〈0.05）. The recovery state of anastomosis stoma in experimental group was superior to that of control group （P〈0.05）. Conclusion The anastomosis of intestine by using medical adhesive is a feasible,convenient method,with saving time,close of anastomosis stoma and good healing.

关 键 词：医用胶 内支架 肠管吻合 动物实验 

分 类 号：R656.7[医药卫生—外科学]