白介素-4、白介素-5在鼻息肉及鼻息肉病组织中的表达  

Expression of interleukin-4 and interleukin-5 in human nasal polyps and polyposis

作　　者：任秀敏[1] 何强[1] 蒋新霞[1] 

机构地区：[1]河北医科大学第二医院耳鼻喉科,石家庄市050000

出　　处：《河北医药》2009年第22期3036-3038,共3页Hebei Medical Journal

摘　　要：目的探讨白介素-4(IL-4)、白介素-5(IL-5)和嗜酸性粒细胞(EOS)在人类鼻息肉及鼻息肉病中的表达情况。方法采用免疫组织化学SP方法检测30例鼻息肉患者(鼻息肉组)、25例鼻息肉病患者(鼻息肉病组)的息肉组织及10例中鼻甲黏膜(对照组)中IL-4、IL-5的表达情况,同时以HE染色计数各组织中EOS的浸润程度。结果IL-4、IL-5在对照组、鼻息肉组及鼻息肉病组间呈递增性表达(P<0.01),且后2组差异均有统计学意义(P<0.01)。结论炎性细胞因子IL-4和IL-5在鼻息肉的发病中起重要作用。Objective To investigate the expression of IL-4 and IL-5 in human nasal polyps and polyposis. Methods The immunohistochemical method was used to detect the expressions of IL-4,IL-5 and eosinophilic granulocyte （ESO） in 65 cases of middle turbinate,nasal polyps and nasal polyposis,and the perceatage of positive area in each group was culculated. Results There were significant differences in the expressions of IL-4 and IL-5 between any two groups（P〈0.01）. Conclusion IL-4 and IL-5 play an important role in the pathogenesis of nasal polyps,and both of them can promote the production of EOS.

关 键 词：鼻息肉 鼻息肉病 IL-4 IL-5 嗜酸性粒细胞 

分 类 号：R765.25[医药卫生—耳鼻咽喉科]